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Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models
Laboratory of Neurochemistry, National Institute of Pediatrics, 04530, D.F., Mexico
Laboratory of Pharmacology, National Institute of Pediatrics, 04530, D.F., Mexico
Department of Endocrinology, National Institute of Pediatrics, 04530, D.F., Mexico
Unit of Support to Research, National Institute of Rehabilitation, 14389, D.F., Mexico
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 9 October 2012; in revised form: 6 November 2012 / Accepted: 18 December 2012 / Published: 14 January 2013
Abstract: Oxidative stress, a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with systemic diseases, and diseases affecting the central nervous system. Epilepsy is a chronic neurological disorder with refractoriness to drug therapy at about 30%. Currently, experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy. Hence, the aim of this review is to present information in order to facilitate the handling of this evidence and determine the therapeutic impact of the biochemical status for this pathology.
Keywords: oxidative stress; free radicals; refractory epilepsy; pharmacoresistant epilepsy
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Cardenas-Rodriguez, N.; Huerta-Gertrudis, B.; Rivera-Espinosa, L.; Montesinos-Correa, H.; Bandala, C.; Carmona-Aparicio, L.; Coballase-Urrutia, E. Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models. Int. J. Mol. Sci. 2013, 14, 1455-1476.
Cardenas-Rodriguez N, Huerta-Gertrudis B, Rivera-Espinosa L, Montesinos-Correa H, Bandala C, Carmona-Aparicio L, Coballase-Urrutia E. Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models. International Journal of Molecular Sciences. 2013; 14(1):1455-1476.
Cardenas-Rodriguez, Noemi; Huerta-Gertrudis, Bernardino; Rivera-Espinosa, Liliana; Montesinos-Correa, Hortencia; Bandala, Cindy; Carmona-Aparicio, Liliana; Coballase-Urrutia, Elvia. 2013. "Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models." Int. J. Mol. Sci. 14, no. 1: 1455-1476.