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Int. J. Mol. Sci. 2012, 13(9), 11323-11332; doi:10.3390/ijms130911323
Article

A Novel Collection of snRNA-Like Promoters with Tissue-Specific Transcription Properties

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Received: 8 August 2012; in revised form: 28 August 2012 / Accepted: 30 August 2012 / Published: 11 September 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: We recently identified a novel dataset of snRNA-like trascriptional units in the human genome. The investigation of a subset of these elements showed that they play relevant roles in physiology and/or pathology. In this work we expand our collection of small RNAs taking advantage of a newly developed algorithm able to identify genome sequence stretches with RNA polymerase (pol) III type 3 promoter features thus constituting putative pol III binding sites. The bioinformatic analysis of a subset of these elements that map in introns of protein-coding genes in antisense configuration suggest their association with alternative splicing, similarly to other recently characterized small RNAs. Interestingly, the analysis of the transcriptional activity of these novel promoters shows that they are active in a cell-type specific manner, in accordance with the emerging body of evidence of a tissue/cell-specific activity of pol III.
Keywords: RNA polymerase III; alternative splicing; non-coding RNA; small nuclear RNA RNA polymerase III; alternative splicing; non-coding RNA; small nuclear RNA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Garritano, S.; Gigoni, A.; Costa, D.; Malatesta, P.; Florio, T.; Cancedda, R.; Pagano, A. A Novel Collection of snRNA-Like Promoters with Tissue-Specific Transcription Properties. Int. J. Mol. Sci. 2012, 13, 11323-11332.

AMA Style

Garritano S, Gigoni A, Costa D, Malatesta P, Florio T, Cancedda R, Pagano A. A Novel Collection of snRNA-Like Promoters with Tissue-Specific Transcription Properties. International Journal of Molecular Sciences. 2012; 13(9):11323-11332.

Chicago/Turabian Style

Garritano, Sonia; Gigoni, Arianna; Costa, Delfina; Malatesta, Paolo; Florio, Tullio; Cancedda, Ranieri; Pagano, Aldo. 2012. "A Novel Collection of snRNA-Like Promoters with Tissue-Specific Transcription Properties." Int. J. Mol. Sci. 13, no. 9: 11323-11332.



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