Int. J. Mol. Sci. 2012, 13(9), 11063-11070; doi:10.3390/ijms130911063
Case Report

Successful Treatment of Liver Aspergilloma by Caspofungin Acetate First-Line Therapy in a Non-Immunocompromised Patient

Qing-Xian Bai 1,* email, Yi Huan 2 email, Jian-Hong Wang 1 email, Li-Jie Yang 1 email and Hong-Juan Dong 1 email
1 Department of Hematology, State Allogeneic Hematopoietic Stem Cell Transplantation Center, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China 2 Department of Radiology and Medical Imaging Center, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
* Author to whom correspondence should be addressed.
Received: 18 July 2012; in revised form: 20 August 2012 / Accepted: 29 August 2012 / Published: 6 September 2012
(This article belongs to the Special Issue Molecular Self-Assembly 2012)
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Abstract: Aspergillosis remains to be a life-threatening complication in immunocompromised patients. However, Aspergillus infection can be observed in non-immunocompromised individuals in rare cases. We report a case of liver aspergilloma in a chronic aplastic anemia patient under relatively intact immune status. Therapeutic strategy for this rare condition was extensively discussed and caspofungin acetate single agent first-line therapy was applied after careful consideration. Encouraging clinical and radiologic improvements were achieved in response to the antifungal salvage. Our long-term follow-up study also revealed a favorable prognosis. Based on this experience, we suggest caspofungin acetate as first-line therapy for treatment plans of liver aspergilloma.
Keywords: aspergillosis; liver; Aspergillus fumigatus; caspofungin acetate

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MDPI and ACS Style

Bai, Q.-X.; Huan, Y.; Wang, J.-H.; Yang, L.-J.; Dong, H.-J. Successful Treatment of Liver Aspergilloma by Caspofungin Acetate First-Line Therapy in a Non-Immunocompromised Patient. Int. J. Mol. Sci. 2012, 13, 11063-11070.

AMA Style

Bai Q-X, Huan Y, Wang J-H, Yang L-J, Dong H-J. Successful Treatment of Liver Aspergilloma by Caspofungin Acetate First-Line Therapy in a Non-Immunocompromised Patient. International Journal of Molecular Sciences. 2012; 13(9):11063-11070.

Chicago/Turabian Style

Bai, Qing-Xian; Huan, Yi; Wang, Jian-Hong; Yang, Li-Jie; Dong, Hong-Juan. 2012. "Successful Treatment of Liver Aspergilloma by Caspofungin Acetate First-Line Therapy in a Non-Immunocompromised Patient." Int. J. Mol. Sci. 13, no. 9: 11063-11070.

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