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Int. J. Mol. Sci. 2012, 13(8), 10296-10304; doi:10.3390/ijms130810296

Effects of Humidity and Surfaces on the Melt Crystallization of Ibuprofen

Department of Chemical Engineering, Soongsil University, Seoul 156-743, Korea
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Received: 19 July 2012 / Revised: 4 August 2012 / Accepted: 16 August 2012 / Published: 17 August 2012
(This article belongs to the Special Issue Molecular Self-Assembly 2012)
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Abstract

Melt crystallization of ibuprofen was studied to understand the effects of humidity and surfaces. The molecular self-assembly during the amorphous-to-crystal transformation was examined in terms of the nucleation and growth of the crystals. The crystallization was on Al, Au, and self-assembled monolayers with –CH3, –OH, and –COOH functional groups. Effects of the humidity were studied at room temperature (18–20 °C) with relative humidity 33%, 75%, and 100%. Effects of the surfaces were observed at −20 °C (relative humidity 36%) to enable close monitoring with slower crystal growth. The nucleation time of ibuprofen was faster at high humidity conditions probably due to the local formation of the unfavorable ibuprofen melt/water interface. The crystal morphologies of ibuprofen were governed by the nature of the surfaces, and they could be associated with the growth kinetics by the Avrami equation. The current study demonstrated the effective control of the melt crystallization of ibuprofen through the melt/atmosphere and melt/surface interfaces.
Keywords: crystallization; ibuprofen; melt; humidity; surfaces crystallization; ibuprofen; melt; humidity; surfaces
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lee, D.-J.; Lee, S.; Kim, I.W. Effects of Humidity and Surfaces on the Melt Crystallization of Ibuprofen. Int. J. Mol. Sci. 2012, 13, 10296-10304.

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