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The Dual Role of Inflammation in Colon Carcinogenesis
AbstractChronic inflammation characterizing patients with inflammatory bowel disease (IBD) represents a major risk factor for the development of colorectal cancer. Mechanisms underlying this neoplastic transformation are not fully understood though studies in experimental models of colon carcinogenesis suggest that inflammatory cell-derived cytokines either directly or indirectly stimulate the uncontrolled growth of cancer cells. Nevertheless, under specific inflammatory conditions, immune cells can boost an anti-tumor immune response with the down-stream effect of eliminating dysplastic and cancerous cells. This review outlines the beneficial and detrimental role of inflammation in colon carcinogenesis.
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Monteleone, G.; Pallone, F.; Stolfi, C. The Dual Role of Inflammation in Colon Carcinogenesis. Int. J. Mol. Sci. 2012, 13, 11071-11084.View more citation formats
Monteleone G, Pallone F, Stolfi C. The Dual Role of Inflammation in Colon Carcinogenesis. International Journal of Molecular Sciences. 2012; 13(9):11071-11084.Chicago/Turabian Style
Monteleone, Giovanni; Pallone, Francesco; Stolfi, Carmine. 2012. "The Dual Role of Inflammation in Colon Carcinogenesis." Int. J. Mol. Sci. 13, no. 9: 11071-11084.