Int. J. Mol. Sci. 2012, 13(9), 11071-11084; doi:10.3390/ijms130911071
Review

The Dual Role of Inflammation in Colon Carcinogenesis

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Received: 1 August 2012; in revised form: 28 August 2012 / Accepted: 28 August 2012 / Published: 6 September 2012
(This article belongs to the Special Issue Advances in Molecular Oncology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Chronic inflammation characterizing patients with inflammatory bowel disease (IBD) represents a major risk factor for the development of colorectal cancer. Mechanisms underlying this neoplastic transformation are not fully understood though studies in experimental models of colon carcinogenesis suggest that inflammatory cell-derived cytokines either directly or indirectly stimulate the uncontrolled growth of cancer cells. Nevertheless, under specific inflammatory conditions, immune cells can boost an anti-tumor immune response with the down-stream effect of eliminating dysplastic and cancerous cells. This review outlines the beneficial and detrimental role of inflammation in colon carcinogenesis.
Keywords: colitis-associated colon cancer; IBD; ulcerative colitis; AOM + DSS; tumor immunosurveillance; T cells; inflammation; IL-21; IL-6; IL-17
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MDPI and ACS Style

Monteleone, G.; Pallone, F.; Stolfi, C. The Dual Role of Inflammation in Colon Carcinogenesis. Int. J. Mol. Sci. 2012, 13, 11071-11084.

AMA Style

Monteleone G, Pallone F, Stolfi C. The Dual Role of Inflammation in Colon Carcinogenesis. International Journal of Molecular Sciences. 2012; 13(9):11071-11084.

Chicago/Turabian Style

Monteleone, Giovanni; Pallone, Francesco; Stolfi, Carmine. 2012. "The Dual Role of Inflammation in Colon Carcinogenesis." Int. J. Mol. Sci. 13, no. 9: 11071-11084.


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