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Design and Synthesis of Binding Growth Factors
AbstractGrowth factors play important roles in tissue regeneration. However, because of their instability and diffusible nature, improvements in their performance would be desirable for therapeutic applications. Conferring binding affinities would be one way to improve their applicability. Here we review techniques for conjugating growth factors to polypeptides with particular affinities. Conjugation has been designed at the level of gene fusion and of polypeptide ligation. We summarize and discuss the designs and applications of binding growth factors prepared by such conjugation approaches.
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Tada, S.; Kitajima, T.; Ito, Y. Design and Synthesis of Binding Growth Factors. Int. J. Mol. Sci. 2012, 13, 6053-6072.View more citation formats
Tada S, Kitajima T, Ito Y. Design and Synthesis of Binding Growth Factors. International Journal of Molecular Sciences. 2012; 13(5):6053-6072.Chicago/Turabian Style
Tada, Seiichi; Kitajima, Takashi; Ito, Yoshihiro. 2012. "Design and Synthesis of Binding Growth Factors." Int. J. Mol. Sci. 13, no. 5: 6053-6072.