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Int. J. Mol. Sci. 2012, 13(4), 5179-5194; doi:10.3390/ijms13045179

Filamentous Bacteriophage Fd as an Antigen Delivery System in Vaccination

Institute of Genetics and Biophysics, CNR, via P. Castellino 111, 80131, Naples, Italy
Institute of Protein Biochemistry, CNR, via P. Castellino 111, 80131, Naples, Italy
Authors to whom correspondence should be addressed.
Received: 28 January 2012 / Revised: 29 February 2012 / Accepted: 19 April 2012 / Published: 24 April 2012
(This article belongs to the Special Issue Phage Display)
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Peptides displayed on the surface of filamentous bacteriophage fd are able to induce humoral as well as cell-mediated immune responses, which makes phage particles an attractive antigen delivery system to design new vaccines. The immune response induced by phage-displayed peptides can be enhanced by targeting phage particles to the professional antigen presenting cells, utilizing a single-chain antibody fragment that binds dendritic cell receptor DEC-205. Here, we review recent advances in the use of filamentous phage fd as a platform for peptide vaccines, with a special focus on the use of phage fd as an antigen delivery platform for peptide vaccines in Alzheimer’s Disease and cancer.
Keywords: vaccine; antigen delivery system; bacteriophage fd vaccine; antigen delivery system; bacteriophage fd

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Prisco, A.; De Berardinis, P. Filamentous Bacteriophage Fd as an Antigen Delivery System in Vaccination. Int. J. Mol. Sci. 2012, 13, 5179-5194.

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