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Int. J. Mol. Sci. 2012, 13(4), 5179-5194; doi:10.3390/ijms13045179
Review

Filamentous Bacteriophage Fd as an Antigen Delivery System in Vaccination

1,*  and 2,*
1 Institute of Genetics and Biophysics, CNR, via P. Castellino 111, 80131, Naples, Italy 2 Institute of Protein Biochemistry, CNR, via P. Castellino 111, 80131, Naples, Italy
* Authors to whom correspondence should be addressed.
Received: 28 January 2012 / Revised: 29 February 2012 / Accepted: 19 April 2012 / Published: 24 April 2012
(This article belongs to the Special Issue Phage Display)
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Abstract

Peptides displayed on the surface of filamentous bacteriophage fd are able to induce humoral as well as cell-mediated immune responses, which makes phage particles an attractive antigen delivery system to design new vaccines. The immune response induced by phage-displayed peptides can be enhanced by targeting phage particles to the professional antigen presenting cells, utilizing a single-chain antibody fragment that binds dendritic cell receptor DEC-205. Here, we review recent advances in the use of filamentous phage fd as a platform for peptide vaccines, with a special focus on the use of phage fd as an antigen delivery platform for peptide vaccines in Alzheimer’s Disease and cancer.
Keywords: vaccine; antigen delivery system; bacteriophage fd vaccine; antigen delivery system; bacteriophage fd
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Prisco, A.; De Berardinis, P. Filamentous Bacteriophage Fd as an Antigen Delivery System in Vaccination. Int. J. Mol. Sci. 2012, 13, 5179-5194.

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