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Int. J. Mol. Sci. 2012, 13(4), 4202-4232; doi:10.3390/ijms13044202
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Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health

1,* , 2
,
3
 and
4
1 Musculoskeletal Research Group, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, The University of Nottingham, Sutton Bonington, LE12 5RD, UK 2 Bone and Cartilage Research Unit, Institute of Pathology, University of Liège, Sart-Tilman, 4000 Liège, Belgium 3 Department of Biological Chemistry and Nutrition, University of Hohenheim, D-70593 Stuttgart, Germany 4 Musculoskeletal Research Group, Institute of Anatomy, Ludwig-Maximilian-University Munich, Pettenkoferstrasse 11, D-80336 Munich, Germany
* Author to whom correspondence should be addressed.
Received: 27 February 2012 / Revised: 12 March 2012 / Accepted: 19 March 2012 / Published: 30 March 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surface receptors and activate inflammatory signaling pathways culminating with the activation of nuclear factor κB (NF-κB), a transcription factor that can be triggered by a host of stress-related stimuli including, excessive mechanical stress and ECM degradation products. Once activated, NF-κB regulates the expression of many cytokines, chemokines, adhesion molecules, inflammatory mediators, and several matrix-degrading enzymes. Therefore, proinflammatory cytokines, their cell surface receptors, NF-κB and downstream signaling pathways are therapeutic targets in OA. This paper critically reviews the recent literature and outlines the potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA to determine whether these phytochemicals can be used as functional foods.
Keywords: phytochemical; curcumin; resveratrol; articular cartilage; osteoarthritis; OA; rheumatoid arthritis; RA; functional food phytochemical; curcumin; resveratrol; articular cartilage; osteoarthritis; OA; rheumatoid arthritis; RA; functional food
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Mobasheri, A.; Henrotin, Y.; Biesalski, H.-K.; Shakibaei, M. Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health. Int. J. Mol. Sci. 2012, 13, 4202-4232.

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