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Int. J. Mol. Sci. 2012, 13(4), 4202-4232; doi:10.3390/ijms13044202
Review

Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health

1,* , 2
, 3
 and 4
Received: 27 February 2012; in revised form: 12 March 2012 / Accepted: 19 March 2012 / Published: 30 March 2012
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surface receptors and activate inflammatory signaling pathways culminating with the activation of nuclear factor κB (NF-κB), a transcription factor that can be triggered by a host of stress-related stimuli including, excessive mechanical stress and ECM degradation products. Once activated, NF-κB regulates the expression of many cytokines, chemokines, adhesion molecules, inflammatory mediators, and several matrix-degrading enzymes. Therefore, proinflammatory cytokines, their cell surface receptors, NF-κB and downstream signaling pathways are therapeutic targets in OA. This paper critically reviews the recent literature and outlines the potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA to determine whether these phytochemicals can be used as functional foods.
Keywords: phytochemical; curcumin; resveratrol; articular cartilage; osteoarthritis; OA; rheumatoid arthritis; RA; functional food phytochemical; curcumin; resveratrol; articular cartilage; osteoarthritis; OA; rheumatoid arthritis; RA; functional food
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mobasheri, A.; Henrotin, Y.; Biesalski, H.-K.; Shakibaei, M. Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health. Int. J. Mol. Sci. 2012, 13, 4202-4232.

AMA Style

Mobasheri A, Henrotin Y, Biesalski H-K, Shakibaei M. Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health. International Journal of Molecular Sciences. 2012; 13(4):4202-4232.

Chicago/Turabian Style

Mobasheri, Ali; Henrotin, Yves; Biesalski, Hans-Konrad; Shakibaei, Mehdi. 2012. "Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health." Int. J. Mol. Sci. 13, no. 4: 4202-4232.



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