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Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health
Musculoskeletal Research Group, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, The University of Nottingham, Sutton Bonington, LE12 5RD, UK
Bone and Cartilage Research Unit, Institute of Pathology, University of Liège, Sart-Tilman, 4000 Liège, Belgium
Department of Biological Chemistry and Nutrition, University of Hohenheim, D-70593 Stuttgart, Germany
Musculoskeletal Research Group, Institute of Anatomy, Ludwig-Maximilian-University Munich, Pettenkoferstrasse 11, D-80336 Munich, Germany
* Author to whom correspondence should be addressed.
Received: 27 February 2012; in revised form: 12 March 2012 / Accepted: 19 March 2012 / Published: 30 March 2012
Abstract: Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surface receptors and activate inflammatory signaling pathways culminating with the activation of nuclear factor κB (NF-κB), a transcription factor that can be triggered by a host of stress-related stimuli including, excessive mechanical stress and ECM degradation products. Once activated, NF-κB regulates the expression of many cytokines, chemokines, adhesion molecules, inflammatory mediators, and several matrix-degrading enzymes. Therefore, proinflammatory cytokines, their cell surface receptors, NF-κB and downstream signaling pathways are therapeutic targets in OA. This paper critically reviews the recent literature and outlines the potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA to determine whether these phytochemicals can be used as functional foods.
Keywords: phytochemical; curcumin; resveratrol; articular cartilage; osteoarthritis; OA; rheumatoid arthritis; RA; functional food
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Mobasheri, A.; Henrotin, Y.; Biesalski, H.-K.; Shakibaei, M. Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health. Int. J. Mol. Sci. 2012, 13, 4202-4232.
Mobasheri A, Henrotin Y, Biesalski H-K, Shakibaei M. Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health. International Journal of Molecular Sciences. 2012; 13(4):4202-4232.
Mobasheri, Ali; Henrotin, Yves; Biesalski, Hans-Konrad; Shakibaei, Mehdi. 2012. "Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health." Int. J. Mol. Sci. 13, no. 4: 4202-4232.