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• Mobasheri, A
• Henrotin, Y
• Biesalski, H
• Shakibaei, M
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• Mobasheri, A
• Henrotin, Y
• Biesalski, H
• Shakibaei, M
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• Mobasheri, A
• Henrotin, Y
• Biesalski, H
• Shakibaei, M

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Int. J. Mol. Sci. 2012, 13(4), 4202-4232; doi:10.3390/ijms13044202

Review

Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health

Ali Mobasheri ^1,* , Yves Henrotin ² , Hans-Konrad Biesalski ³  and Mehdi Shakibaei ⁴

¹ Musculoskeletal Research Group, School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, The University of Nottingham, Sutton Bonington, LE12 5RD, UK ² Bone and Cartilage Research Unit, Institute of Pathology, University of Liège, Sart-Tilman, 4000 Liège, Belgium ³ Department of Biological Chemistry and Nutrition, University of Hohenheim, D-70593 Stuttgart, Germany ⁴ Musculoskeletal Research Group, Institute of Anatomy, Ludwig-Maximilian-University Munich, Pettenkoferstrasse 11, D-80336 Munich, Germany

* Author to whom correspondence should be addressed.

Received: 27 February 2012; in revised form: 12 March 2012 / Accepted: 19 March 2012 / Published: 30 March 2012

(This article belongs to the Section Bioactives and Nutraceuticals)

Download PDF Full-Text [728 KB, uploaded 30 March 2012 12:03 CEST]

Abstract: Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surface receptors and activate inflammatory signaling pathways culminating with the activation of nuclear factor κB (NF-κB), a transcription factor that can be triggered by a host of stress-related stimuli including, excessive mechanical stress and ECM degradation products. Once activated, NF-κB regulates the expression of many cytokines, chemokines, adhesion molecules, inflammatory mediators, and several matrix-degrading enzymes. Therefore, proinflammatory cytokines, their cell surface receptors, NF-κB and downstream signaling pathways are therapeutic targets in OA. This paper critically reviews the recent literature and outlines the potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA to determine whether these phytochemicals can be used as functional foods.

Keywords: phytochemical; curcumin; resveratrol; articular cartilage; osteoarthritis; OA; rheumatoid arthritis; RA; functional food

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