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• Ren, H
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Int. J. Mol. Sci. 2012, 13(12), 16769-16778; doi:10.3390/ijms131216769

Review

The Role of Dicer in DNA Damage Repair

Kai-Fu Tang *  and Hong Ren *

Key Laboratory of Molecular Biology for Infectious Diseases of the State Ministry of Education, Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

* Authors to whom correspondence should be addressed.

Received: 29 September 2012; in revised form: 9 November 2012 / Accepted: 12 November 2012 / Published: 7 December 2012

Download PDF Full-Text [166 KB, uploaded 7 December 2012 09:12 CET]

Abstract: Dicer is the key component of the RNA interference pathway. Our group and others have reported that knockdown or knockout of Dicer leads to DNA damage in mammalian cells. Two groups recently showed that efficiency of DNA damage repair was greatly reduced in Dicer-deficient cells and that Dicer-dependent small RNAs (~21 nucleotides) produced from the sequences in the vicinity of DNA double-strand break sites were essential for DNA damage repair. Moreover, accumulating data have suggested that miroRNAs play pivotal roles in DNA damage repair. In this review, we discuss the molecular mechanisms by which loss of Dicer leads to DNA damage, as well as the role of Dicer in tumorigenesis.

Keywords: dicer; DNA damage; tumorigenesis

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