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Int. J. Mol. Sci. 2012, 13(12), 16769-16778; doi:10.3390/ijms131216769
Review
The Role of Dicer in DNA Damage Repair
Received: 29 September 2012 / Revised: 9 November 2012 / Accepted: 12 November 2012 / Published: 7 December 2012
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Abstract: Dicer is the key component of the RNA interference pathway. Our group and others have reported that knockdown or knockout of Dicer leads to DNA damage in mammalian cells. Two groups recently showed that efficiency of DNA damage repair was greatly reduced in Dicer-deficient cells and that Dicer-dependent small RNAs (~21 nucleotides) produced from the sequences in the vicinity of DNA double-strand break sites were essential for DNA damage repair. Moreover, accumulating data have suggested that miroRNAs play pivotal roles in DNA damage repair. In this review, we discuss the molecular mechanisms by which loss of Dicer leads to DNA damage, as well as the role of Dicer in tumorigenesis.
Keywords:
dicer; DNA damage; tumorigenesis
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MDPI and ACS Style
Tang, K.-F.; Ren, H. The Role of Dicer in DNA Damage Repair. Int. J. Mol. Sci. 2012, 13, 16769-16778.
AMA StyleTang K-F, Ren H. The Role of Dicer in DNA Damage Repair. International Journal of Molecular Sciences. 2012; 13(12):16769-16778.
Chicago/Turabian StyleTang, Kai-Fu; Ren, Hong. 2012. "The Role of Dicer in DNA Damage Repair." Int. J. Mol. Sci. 13, no. 12: 16769-16778.
Int. J. Mol. Sci.
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