Int. J. Mol. Sci. 2012, 13(12), 16769-16778; doi:10.3390/ijms131216769
The Role of Dicer in DNA Damage Repair
Key Laboratory of Molecular Biology for Infectious Diseases of the State Ministry of Education, Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
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Received: 29 September 2012 / Revised: 9 November 2012 / Accepted: 12 November 2012 / Published: 7 December 2012
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Abstract
Dicer is the key component of the RNA interference pathway. Our group and others have reported that knockdown or knockout of Dicer leads to DNA damage in mammalian cells. Two groups recently showed that efficiency of DNA damage repair was greatly reduced in Dicer-deficient cells and that Dicer-dependent small RNAs (~21 nucleotides) produced from the sequences in the vicinity of DNA double-strand break sites were essential for DNA damage repair. Moreover, accumulating data have suggested that miroRNAs play pivotal roles in DNA damage repair. In this review, we discuss the molecular mechanisms by which loss of Dicer leads to DNA damage, as well as the role of Dicer in tumorigenesis.Keywords:
dicer; DNA damage; tumorigenesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Tang, K.-F.; Ren, H. The Role of Dicer in DNA Damage Repair. Int. J. Mol. Sci. 2012, 13, 16769-16778.
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