CiteULike
Facebook
Mendeley
Twitter
Open AccessThis article is
Download PDF Full-Text [166 KB, uploaded 19 June 2014 04:35 CEST]
MDPI and ACS Style
- freely available
- re-usable
Int. J. Mol. Sci. 2012, 13(12), 16769-16778; doi:10.3390/ijms131216769
Review
The Role of Dicer in DNA Damage Repair
Received: 29 September 2012; in revised form: 9 November 2012 / Accepted: 12 November 2012 / Published: 7 December 2012
This is an open access article distributed under the
Creative Commons Attribution License which permits unrestricted use, distribution,
and reproduction in any medium, provided the original work is properly cited.
Abstract: Dicer is the key component of the RNA interference pathway. Our group and others have reported that knockdown or knockout of Dicer leads to DNA damage in mammalian cells. Two groups recently showed that efficiency of DNA damage repair was greatly reduced in Dicer-deficient cells and that Dicer-dependent small RNAs (~21 nucleotides) produced from the sequences in the vicinity of DNA double-strand break sites were essential for DNA damage repair. Moreover, accumulating data have suggested that miroRNAs play pivotal roles in DNA damage repair. In this review, we discuss the molecular mechanisms by which loss of Dicer leads to DNA damage, as well as the role of Dicer in tumorigenesis.
Keywords: dicer; DNA damage; tumorigenesis
Download PDF Full-Text [166 KB, uploaded 19 June 2014 04:35 CEST]
Export to BibTeX | EndNote
MDPI and ACS Style
Tang, K.-F.; Ren, H. The Role of Dicer in DNA Damage Repair. Int. J. Mol. Sci. 2012, 13, 16769-16778.
AMA StyleTang K-F, Ren H. The Role of Dicer in DNA Damage Repair. International Journal of Molecular Sciences. 2012; 13(12):16769-16778.
Chicago/Turabian StyleTang, Kai-Fu; Ren, Hong. 2012. "The Role of Dicer in DNA Damage Repair." Int. J. Mol. Sci. 13, no. 12: 16769-16778.
Int. J. Mol. Sci.
EISSN 1422-0067
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert