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Flavin-Dependent Enzymes in Cancer Prevention
AbstractStatistical studies have demonstrated that various agents may reduce the risk of cancer’s development. One of them is activity of flavin-dependent enzymes such as flavin-containing monooxygenase (FMO)GS-OX1, FAD-dependent 5,10-methylenetetrahydrofolate reductase and flavin-dependent monoamine oxidase. In the last decade, many papers concerning their structure, reaction mechanism and role in the cancer prevention were published. In our work, we provide a more in-depth analysis of flavin-dependent enzymes and their contribution to the cancer prevention. We present the actual knowledge about the glucosinolate synthesized by flavin-containing monooxygenase (FMO)GS-OX1 and its role in cancer prevention, discuss the influence of mutations in FAD-dependent 5,10-methylenetetrahydrofolate reductase on the cancer risk, and describe FAD as an important cofactor for the demethylation of histons. We also present our views on the role of riboflavin supplements in the prevention against cancer.
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Wojcieszyńska, D.; Hupert-Kocurek, K.; Guzik, U. Flavin-Dependent Enzymes in Cancer Prevention. Int. J. Mol. Sci. 2012, 13, 16751-16768.View more citation formats
Wojcieszyńska D, Hupert-Kocurek K, Guzik U. Flavin-Dependent Enzymes in Cancer Prevention. International Journal of Molecular Sciences. 2012; 13(12):16751-16768.Chicago/Turabian Style
Wojcieszyńska, Danuta; Hupert-Kocurek, Katarzyna; Guzik, Urszula. 2012. "Flavin-Dependent Enzymes in Cancer Prevention." Int. J. Mol. Sci. 13, no. 12: 16751-16768.
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