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Form Follows Function: Structural and Catalytic Variation in the Class A Flavoprotein Monooxygenases
Int. J. Mol. Sci. 2012, 13(12), 16751-16768; doi:10.3390/ijms131216751
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Flavin-Dependent Enzymes in Cancer Prevention

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Received: 20 September 2012 / Revised: 26 November 2012 / Accepted: 4 December 2012 / Published: 7 December 2012
(This article belongs to the Special Issue Flavins)
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Abstract

Statistical studies have demonstrated that various agents may reduce the risk of cancer’s development. One of them is activity of flavin-dependent enzymes such as flavin-containing monooxygenase (FMO)GS-OX1, FAD-dependent 5,10-methylenetetrahydrofolate reductase and flavin-dependent monoamine oxidase. In the last decade, many papers concerning their structure, reaction mechanism and role in the cancer prevention were published. In our work, we provide a more in-depth analysis of flavin-dependent enzymes and their contribution to the cancer prevention. We present the actual knowledge about the glucosinolate synthesized by flavin-containing monooxygenase (FMO)GS-OX1 and its role in cancer prevention, discuss the influence of mutations in FAD-dependent 5,10-methylenetetrahydrofolate reductase on the cancer risk, and describe FAD as an important cofactor for the demethylation of histons. We also present our views on the role of riboflavin supplements in the prevention against cancer.
Keywords: flavin-containing monooxygenase; methylenetetrahydrofolate reductase; monoamine oxidase flavin-containing monooxygenase; methylenetetrahydrofolate reductase; monoamine oxidase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wojcieszyńska, D.; Hupert-Kocurek, K.; Guzik, U. Flavin-Dependent Enzymes in Cancer Prevention. Int. J. Mol. Sci. 2012, 13, 16751-16768.

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