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Int. J. Mol. Sci. 2012, 13(12), 16658-16667; doi:10.3390/ijms131216658
Article

XRCC3 Gene Polymorphism Is Associated with Survival in Japanese Lung Cancer Patients

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Received: 28 September 2012; in revised form: 7 November 2012 / Accepted: 28 November 2012 / Published: 5 December 2012
(This article belongs to the Section Molecular Pathology)
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Abstract: We focused on OGG1 Ser326Cys, MUTYH Gln324His, APEX1 Asp148Glu, XRCC1 Arg399Gln, and XRCC3 Thr241Met and examined the relationship between the different genotypes and survival of Japanese lung cancer patients. A total of 99 Japanese lung cancer patients were recruited into our study. Clinical data were collected, and genotypes of the target genes were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Survival analysis to verify the impact of these gene polymorphisms on the clinical outcome of lung cancer showed that lung squamous cell carcinoma patients with the Thr/Met genotype at XRCC3 had a significantly shorter survival time than those with the Thr/Thr genotype (13 months versus 48 months; log-rank test, p < 0.0001). Cox regression analysis showed that the carriers of XRCC3 genotypes were at a significantly higher risk [adjusted hazard ratio (HR) = 9.35, 95% confidence interval (CI) = 2.52–34.68, p = 0.001; adjusted HR = 9.05, 95% CI = 1.89–44.39, p = 0.006]. Our results suggest that XRCC3 Thr241Met may act as a favorable prognostic indicator for lung squamous cell carcinoma patients.
Keywords: gene polymorphisms; lung cancer; survival; DNA repair; XRCC3 gene polymorphisms; lung cancer; survival; DNA repair; XRCC3
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Osawa, K.; Nakarai, C.; Uchino, K.; Yoshimura, M.; Tsubota, N.; Takahashi, J.; Kido, Y. XRCC3 Gene Polymorphism Is Associated with Survival in Japanese Lung Cancer Patients. Int. J. Mol. Sci. 2012, 13, 16658-16667.

AMA Style

Osawa K, Nakarai C, Uchino K, Yoshimura M, Tsubota N, Takahashi J, Kido Y. XRCC3 Gene Polymorphism Is Associated with Survival in Japanese Lung Cancer Patients. International Journal of Molecular Sciences. 2012; 13(12):16658-16667.

Chicago/Turabian Style

Osawa, Kayo; Nakarai, Chiaki; Uchino, Kazuya; Yoshimura, Masahiro; Tsubota, Noriaki; Takahashi, Juro; Kido, Yoshiaki. 2012. "XRCC3 Gene Polymorphism Is Associated with Survival in Japanese Lung Cancer Patients." Int. J. Mol. Sci. 13, no. 12: 16658-16667.


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