Int. J. Mol. Sci. 2012, 13(12), 16636-16657; doi:10.3390/ijms131216636

The Implications of Cancer Stem Cells for Cancer Therapy

1email, 1email, 1,* email, 2email and 3,* email
Received: 11 October 2012; in revised form: 21 November 2012 / Accepted: 27 November 2012 / Published: 5 December 2012
(This article belongs to the Special Issue Advances in Molecular Oncology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Surgery, radiotherapy and chemotherapy are universally recognized as the most effective anti-cancer therapies. Despite significant advances directed towards elucidating molecular mechanisms and developing clinical trials, cancer still remains a major public health issue. Recent studies have showed that cancer stem cells (CSCs), a small subpopulation of tumor cells, can generate bulk populations of nontumorigenic cancer cell progeny through the self-renewal and differentiation processes. As CSCs are proposed to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors, development of CSC-targeted therapeutic strategies holds new hope for improving survival and quality of life in patients with cancer. Therapeutic innovations will emerge from a better understanding of the biology and environment of CSCs, which, however, are largely unexplored. This review summarizes the characteristics, evidences and development of CSCs, as well as implications and challenges for cancer treatment.
Keywords: cancer stem cells; differentiation; progenitor; signaling pathway; tumorigenesis
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MDPI and ACS Style

Jiang, W.; Peng, J.; Zhang, Y.; Cho, W.C.S.; Jin, K. The Implications of Cancer Stem Cells for Cancer Therapy. Int. J. Mol. Sci. 2012, 13, 16636-16657.

AMA Style

Jiang W, Peng J, Zhang Y, Cho WCS, Jin K. The Implications of Cancer Stem Cells for Cancer Therapy. International Journal of Molecular Sciences. 2012; 13(12):16636-16657.

Chicago/Turabian Style

Jiang, Wenjing; Peng, Jianhua; Zhang, Yue; Cho, William C.S.; Jin, Kunlin. 2012. "The Implications of Cancer Stem Cells for Cancer Therapy." Int. J. Mol. Sci. 13, no. 12: 16636-16657.

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