Int. J. Mol. Sci. 2012, 13(12), 16430-16443; doi:10.3390/ijms131216430
Article

Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities

Yun-Ting Huang 1,† email, Hsun-Shuo Chang 1,† email, Guei-Jane Wang 2,3 email, Chu-Hung Lin 4 email and Ih-Sheng Chen 1,4,* email
1 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan 2 Research Center, China Medical University Hospital, Taichung 40447, Taiwan 3 Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan 4 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan † These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 24 September 2012; in revised form: 19 November 2012 / Accepted: 21 November 2012 / Published: 3 December 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
PDF Full-text Download PDF Full-Text [284 KB, uploaded 3 December 2012 11:17 CET]
Abstract: Four new endiandric acid analogues, tsangibeilin C (1), tsangibeilin D (2), tricyclotsangibeilin (3) and endiandric acid M (4), one new lignan, beilschminol B (5) and two new sesquiterpenes, (+)-5-hydroxybarbatenal (6) and (4R,5R)-4,5-dihydroxycaryophyll-8(13)-ene (7), together with four known compounds (8–11), were isolated from the roots of Beilschmiedia tsangii (Lauraceae). The structures of 1–7 were determined by spectroscopic techniques. Among the isolates, endiandric acid M (4) exhibited moderate iNOS inhibitory activity, with an IC50 value of 31.70 µM.
Keywords: Beilschmiedia tsangii; Lauraceae; root; endiandric acid; anti-inflammatory activity

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Huang, Y.-T.; Chang, H.-S.; Wang, G.-J.; Lin, C.-H.; Chen, I.-S. Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities. Int. J. Mol. Sci. 2012, 13, 16430-16443.

AMA Style

Huang Y-T, Chang H-S, Wang G-J, Lin C-H, Chen I-S. Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities. International Journal of Molecular Sciences. 2012; 13(12):16430-16443.

Chicago/Turabian Style

Huang, Yun-Ting; Chang, Hsun-Shuo; Wang, Guei-Jane; Lin, Chu-Hung; Chen, Ih-Sheng. 2012. "Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities." Int. J. Mol. Sci. 13, no. 12: 16430-16443.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert