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Int. J. Mol. Sci. 2012, 13(12), 16430-16443; doi:10.3390/ijms131216430
Article

Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities

1,†
, 1,†
, 2,3
, 4
 and 1,4,*
1 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan 2 Research Center, China Medical University Hospital, Taichung 40447, Taiwan 3 Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan 4 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 24 September 2012 / Revised: 19 November 2012 / Accepted: 21 November 2012 / Published: 3 December 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Four new endiandric acid analogues, tsangibeilin C (1), tsangibeilin D (2), tricyclotsangibeilin (3) and endiandric acid M (4), one new lignan, beilschminol B (5) and two new sesquiterpenes, (+)-5-hydroxybarbatenal (6) and (4R,5R)-4,5-dihydroxycaryophyll-8(13)-ene (7), together with four known compounds (811), were isolated from the roots of Beilschmiedia tsangii (Lauraceae). The structures of 17 were determined by spectroscopic techniques. Among the isolates, endiandric acid M (4) exhibited moderate iNOS inhibitory activity, with an IC50 value of 31.70 µM.
Keywords: Beilschmiedia tsangii; Lauraceae; root; endiandric acid; anti-inflammatory activity Beilschmiedia tsangii; Lauraceae; root; endiandric acid; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Huang, Y.-T.; Chang, H.-S.; Wang, G.-J.; Lin, C.-H.; Chen, I.-S. Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities. Int. J. Mol. Sci. 2012, 13, 16430-16443.

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