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Integration of DNA Damage and Repair with Murine Double-Minute 2 (Mdm2) in Tumorigenesis
Department of Pediatrics, Herman B Wells Center for Pediatrics Research, 1044 West Walnut Street, Indianapolis, IN 46202, USA
* Author to whom correspondence should be addressed.
Received: 27 September 2012; in revised form: 27 November 2012 / Accepted: 27 November 2012 / Published: 3 December 2012
Abstract: The alteration of tumorigenic pathways leading to cancer is a degenerative disease process typically involving inactivation of tumor suppressor proteins and hyperactivation of oncogenes. One such oncogenic protein product is the murine double-minute 2, or Mdm2. While, Mdm2 has been primarily associated as the negative regulator of the p53 tumor suppressor protein there are many p53-independent roles demonstrated for this oncogene. DNA damage and chemotherapeutic agents are known to activate Mdm2 and DNA repair pathways. There are five primary DNA repair pathways involved in the maintenance of genomic integrity: Nucleotide excision repair (NER), Base excision repair (BER), Mismatch repair (MMR), Non-homologous end joining (NHEJ) and homologous recombination (HR). In this review, we will briefly describe these pathways and also delineate the functional interaction of Mdm2 with multiple DNA repair proteins. We will illustrate the importance of these interactions with Mdm2 and discuss how this is important for tumor progression, cellular proliferation in cancer.
Keywords: base excision repair; cancer; homologous recombination; mismatch repair; murine double minute-2; non-homologous end joining; nucleotide excision repair
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Lehman, J.A.; Mayo, L.D. Integration of DNA Damage and Repair with Murine Double-Minute 2 (Mdm2) in Tumorigenesis. Int. J. Mol. Sci. 2012, 13, 16373-16386.
Lehman JA, Mayo LD. Integration of DNA Damage and Repair with Murine Double-Minute 2 (Mdm2) in Tumorigenesis. International Journal of Molecular Sciences. 2012; 13(12):16373-16386.
Lehman, Jason A.; Mayo, Lindsey D. 2012. "Integration of DNA Damage and Repair with Murine Double-Minute 2 (Mdm2) in Tumorigenesis." Int. J. Mol. Sci. 13, no. 12: 16373-16386.