Int. J. Mol. Sci. 2012, 13(11), 13881-13893; doi:10.3390/ijms131113881
Article

The Role of Forkhead Box Q1 Transcription Factor in Ovarian Epithelial Carcinomas

1,2email, 2email and 2,* email
Received: 27 September 2012; Accepted: 18 October 2012 / Published: 26 October 2012
(This article belongs to the Special Issue Genes and Pathways in the Pathogenesis of Ovarian Cancer)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The role of the forkhead box Q1 (FOXQ1) transcription factor in cancer pathogenesis has recently emerged. Overexpression of FOXQ1 has been found in a variety of human cancers, and its upregulation has been associated with poor prognosis in colorectal, breast, and non-small cell lung carcinomas. However, the molecular mechanism underlying how FOXQ1 contributes to ovarian epithelial carcinomas remains unclear. To this end, we analyzed gene expression levels in ovarian cancer tissues and cell lines and demonstrated a higher expression level of FOXQ1 in epithelial ovarian cancer cells than that in normal epithelial cells. We then used a human ovarian cancer cell line, SKOV3, which expressed a higher level of FOXQ1, as a cell model to investigate the biological effects of FOXQ1 by using RNA interference. Silencing of FOXQ1 expression using a shRNA knockdown approach affected the expression of several cell cycle regulators, leading to suppressed cell proliferation, reduced cell motility/invasion, and upregulation of epithelial cell markers and the downregulation of mesenchymal cell markers. Taken together, these results suggest that FOXQ1 expression is essential to maintain cell proliferation, motility/invasion, and epithelial-mesenchymal transition phenotypes in ovarian cancer cells.
Keywords: ovarian cancer; FOXQ1; survival; migration; invasion
PDF Full-text Download PDF Full-Text [1866 KB, uploaded 19 June 2014 04:30 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Gao, M.; Shih, I.-M.; Wang, T.-L. The Role of Forkhead Box Q1 Transcription Factor in Ovarian Epithelial Carcinomas. Int. J. Mol. Sci. 2012, 13, 13881-13893.

AMA Style

Gao M, Shih I-M, Wang T-L. The Role of Forkhead Box Q1 Transcription Factor in Ovarian Epithelial Carcinomas. International Journal of Molecular Sciences. 2012; 13(11):13881-13893.

Chicago/Turabian Style

Gao, Min; Shih, Ie-Ming; Wang, Tian-Li. 2012. "The Role of Forkhead Box Q1 Transcription Factor in Ovarian Epithelial Carcinomas." Int. J. Mol. Sci. 13, no. 11: 13881-13893.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert