Int. J. Mol. Sci. 2012, 13(11), 13867-13880; doi:10.3390/ijms131113867
Article

Enhancement of Commercial Antifungal Agents by Kojic Acid

1,* email, 2email, 1email, 3email, 1email, 1,4email, 3email and 1email
Received: 19 September 2012; in revised form: 15 October 2012 / Accepted: 23 October 2012 / Published: 26 October 2012
(This article belongs to the Section Bioactives and Nutraceuticals)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Natural compounds that pose no significant medical or environmental side effects are potential sources of antifungal agents, either in their nascent form or as structural backbones for more effective derivatives. Kojic acid (KA) is one such compound. It is a natural by-product of fungal fermentation commonly employed by food and cosmetic industries. We show that KA greatly lowers minimum inhibitory (MIC) or fungicidal (MFC) concentrations of commercial medicinal and agricultural antifungal agents, amphotericin B (AMB) and strobilurin, respectively, against pathogenic yeasts and filamentous fungi. Assays using two mitogen-activated protein kinase (MAPK) mutants, i.e., sakA∆, mpkC∆, of Aspergillus fumigatus, an agent for human invasive aspergillosis, with hydrogen peroxide (H2O2) or AMB indicate such chemosensitizing activity of KA is most conceivably through disruption of fungal antioxidation systems. KA could be developed as a chemosensitizer to enhance efficacy of certain conventional antifungal drugs or fungicides.
Keywords: Kojic acid; hydrogen peroxide; amphotericin B; strobilurin; chemosensitization
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MDPI and ACS Style

Kim, J.H.; Chang, P.-K.; Chan, K.L.; Faria, N.C.G.; Mahoney, N.; Kim, Y.K.; Martins, M.L.; Campbell, B.C. Enhancement of Commercial Antifungal Agents by Kojic Acid. Int. J. Mol. Sci. 2012, 13, 13867-13880.

AMA Style

Kim JH, Chang P-K, Chan KL, Faria NCG, Mahoney N, Kim YK, Martins ML, Campbell BC. Enhancement of Commercial Antifungal Agents by Kojic Acid. International Journal of Molecular Sciences. 2012; 13(11):13867-13880.

Chicago/Turabian Style

Kim, Jong H.; Chang, Perng-Kuang; Chan, Kathleen L.; Faria, Natália C.G.; Mahoney, Noreen; Kim, Young K.; Martins, Maria L.; Campbell, Bruce C. 2012. "Enhancement of Commercial Antifungal Agents by Kojic Acid." Int. J. Mol. Sci. 13, no. 11: 13867-13880.

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