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Int. J. Mol. Sci. 2013, 14(1), 1179-1196; doi:10.3390/ijms14011179
Review

Hedgehog Signaling Pathway in Ovarian Cancer

1
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, 3
, 1
 and 1,*
Received: 17 December 2012; in revised form: 30 December 2012 / Accepted: 5 January 2013 / Published: 9 January 2013
(This article belongs to the Special Issue Genes and Pathways in the Pathogenesis of Ovarian Cancer)
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Abstract: Despite advances in surgical and chemotherapeutic treatment options, less than 50% of patients with advanced-stage ovarian cancer survive five years after initial diagnosis. In this regard, novel treatment approaches are warranted utilizing molecularly targeted therapies directed against particular components of specific signaling pathways which are required for tumor development and progression. One molecular pathway of interest is the hedgehog (Hh) signaling pathway. Activation of the Hh pathway has been observed in several cancer types, including ovarian cancer. This review highlights the crucial role of Hh signaling in the development and progression of ovarian cancer and might lead to a better understanding of the Hh signaling in ovarian tumorigenesis, thus encouraging the investigation of novel targeted therapies.
Keywords: Hedgehog pathway; ovarian cancer; carcinogenesis; targeted therapy Hedgehog pathway; ovarian cancer; carcinogenesis; targeted therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Szkandera, J.; Kiesslich, T.; Haybaeck, J.; Gerger, A.; Pichler, M. Hedgehog Signaling Pathway in Ovarian Cancer. Int. J. Mol. Sci. 2013, 14, 1179-1196.

AMA Style

Szkandera J, Kiesslich T, Haybaeck J, Gerger A, Pichler M. Hedgehog Signaling Pathway in Ovarian Cancer. International Journal of Molecular Sciences. 2013; 14(1):1179-1196.

Chicago/Turabian Style

Szkandera, Joanna; Kiesslich, Tobias; Haybaeck, Johannes; Gerger, Armin; Pichler, Martin. 2013. "Hedgehog Signaling Pathway in Ovarian Cancer." Int. J. Mol. Sci. 14, no. 1: 1179-1196.


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