Next Article in Journal
Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae
Next Article in Special Issue
Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening
Previous Article in Journal
Interaction of Proteins Identified in Human Thyroid Cells
Previous Article in Special Issue
The Role of Forkhead Box Q1 Transcription Factor in Ovarian Epithelial Carcinomas
Int. J. Mol. Sci. 2013, 14(1), 1179-1196; doi:10.3390/ijms14011179

Hedgehog Signaling Pathway in Ovarian Cancer

1 Division of Clinical Oncology, Department of Medicine, Medical University of Graz, 8036 Graz, Austria 2 Department of Internal Medicine I, Paracelsus Medical University/Salzburger Landeskliniken (SALK), 5020 Salzburg, Austria 3 Institute of Pathology, Medical University of Graz, 8036 Graz, Austria
* Author to whom correspondence should be addressed.
Received: 17 December 2012 / Revised: 30 December 2012 / Accepted: 5 January 2013 / Published: 9 January 2013
(This article belongs to the Special Issue Genes and Pathways in the Pathogenesis of Ovarian Cancer)
View Full-Text   |   Download PDF [187 KB, 19 June 2014; original version 19 June 2014]   |   Browse Figures


Despite advances in surgical and chemotherapeutic treatment options, less than 50% of patients with advanced-stage ovarian cancer survive five years after initial diagnosis. In this regard, novel treatment approaches are warranted utilizing molecularly targeted therapies directed against particular components of specific signaling pathways which are required for tumor development and progression. One molecular pathway of interest is the hedgehog (Hh) signaling pathway. Activation of the Hh pathway has been observed in several cancer types, including ovarian cancer. This review highlights the crucial role of Hh signaling in the development and progression of ovarian cancer and might lead to a better understanding of the Hh signaling in ovarian tumorigenesis, thus encouraging the investigation of novel targeted therapies.
Keywords: Hedgehog pathway; ovarian cancer; carcinogenesis; targeted therapy Hedgehog pathway; ovarian cancer; carcinogenesis; targeted therapy
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Szkandera, J.; Kiesslich, T.; Haybaeck, J.; Gerger, A.; Pichler, M. Hedgehog Signaling Pathway in Ovarian Cancer. Int. J. Mol. Sci. 2013, 14, 1179-1196.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert