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Hedgehog Signaling Pathway in Ovarian Cancer
Division of Clinical Oncology, Department of Medicine, Medical University of Graz, 8036 Graz, Austria
Department of Internal Medicine I, Paracelsus Medical University/Salzburger Landeskliniken (SALK), 5020 Salzburg, Austria
Institute of Pathology, Medical University of Graz, 8036 Graz, Austria
* Author to whom correspondence should be addressed.
Received: 17 December 2012; in revised form: 30 December 2012 / Accepted: 5 January 2013 / Published: 9 January 2013
Abstract: Despite advances in surgical and chemotherapeutic treatment options, less than 50% of patients with advanced-stage ovarian cancer survive five years after initial diagnosis. In this regard, novel treatment approaches are warranted utilizing molecularly targeted therapies directed against particular components of specific signaling pathways which are required for tumor development and progression. One molecular pathway of interest is the hedgehog (Hh) signaling pathway. Activation of the Hh pathway has been observed in several cancer types, including ovarian cancer. This review highlights the crucial role of Hh signaling in the development and progression of ovarian cancer and might lead to a better understanding of the Hh signaling in ovarian tumorigenesis, thus encouraging the investigation of novel targeted therapies.
Keywords: Hedgehog pathway; ovarian cancer; carcinogenesis; targeted therapy
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MDPI and ACS Style
Szkandera, J.; Kiesslich, T.; Haybaeck, J.; Gerger, A.; Pichler, M. Hedgehog Signaling Pathway in Ovarian Cancer. Int. J. Mol. Sci. 2013, 14, 1179-1196.
Szkandera J, Kiesslich T, Haybaeck J, Gerger A, Pichler M. Hedgehog Signaling Pathway in Ovarian Cancer. International Journal of Molecular Sciences. 2013; 14(1):1179-1196.
Szkandera, Joanna; Kiesslich, Tobias; Haybaeck, Johannes; Gerger, Armin; Pichler, Martin. 2013. "Hedgehog Signaling Pathway in Ovarian Cancer." Int. J. Mol. Sci. 14, no. 1: 1179-1196.