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Histone Displacement during Nucleotide Excision Repair
Genome Integrity Unit, Danish Cancer Society Research Centre, Strandboulevarden 49, DK-2100 Copenhagen, Denmark
Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 5, CZ-775 15 Olomouc, Czech Republic
Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark
* Authors to whom correspondence should be addressed.
Received: 5 September 2012; in revised form: 29 September 2012 / Accepted: 9 October 2012 / Published: 17 October 2012
Abstract: Nucleotide excision repair (NER) is an important DNA repair mechanism required for cellular resistance against UV light and toxic chemicals such as those found in tobacco smoke. In living cells, NER efficiently detects and removes DNA lesions within the large nuclear macromolecular complex called chromatin. The condensed nature of chromatin inhibits many DNA metabolizing activities, including NER. In order to promote efficient repair, detection of a lesion not only has to activate the NER pathway but also chromatin remodeling. In general, such remodeling is thought on the one hand to precede NER, thus allowing repair proteins to efficiently access DNA. On the other hand, after completion of the repair, the chromatin must be returned to its previous undamaged state. Chromatin remodeling can refer to three separate but interconnected processes, histone post-translational modifications, insertion of histone variants and histone displacement (including nucleosome sliding). Here we review current knowledge, and speculate about current unknowns, regarding those chromatin remodeling activities that physically displace histones before, during and after NER.
Keywords: nucleotide excision repair; histone chaperone; ATP-dependent chromatin remodeling; histone variants
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MDPI and ACS Style
Dinant, C.; Bartek, J.; Bekker-Jensen, S. Histone Displacement during Nucleotide Excision Repair. Int. J. Mol. Sci. 2012, 13, 13322-13337.
Dinant C, Bartek J, Bekker-Jensen S. Histone Displacement during Nucleotide Excision Repair. International Journal of Molecular Sciences. 2012; 13(10):13322-13337.
Dinant, Christoffel; Bartek, Jiri; Bekker-Jensen, Simon. 2012. "Histone Displacement during Nucleotide Excision Repair." Int. J. Mol. Sci. 13, no. 10: 13322-13337.