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ABO Blood Group System and Gastric Cancer: A Case-Control Study and Meta-Analysis
Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 24 July 2012; in revised form: 3 September 2012 / Accepted: 8 October 2012 / Published: 17 October 2012
Abstract: This study focuses on the association between the ABO blood group system and the risk of gastric cancer or Helicobacter pylori infection. The data for the ABO blood group was collected from 1045 cases of gastric cancer, whereby the patient underwent a gastrectomy in Ruijin Hospital, Shanghai. The information on the ABO blood group from 53,026 healthy blood donors was enrolled as control. We searched the Pubmed database on the relationship between ABO blood groups and gastric cancer risk for meta-analysis. In our case-control study, the risk of gastric cancer in blood group A was significantly higher than that in non-A groups (O, B and AB) (odd ratio, OR1.34; 95% confidential interval, CI 1.25–1.44). Compared with non-O groups (A, B and AB), individuals with blood group O demonstrated a reduced risk of gastric cancer (OR = 0.80; 95% CI 0.72–0.88). The proportion of H. pylori infection in blood group A individuals was significantly higher than that in non-A blood groups (OR = 1.42; 95% CI 1.05–1.93). We further combined our data with the published data of others, and crossreferenced the risk of gastric cancer with the blood type, finding consistent evidence that gastric cancer risk in the blood A group was higher than that in the non-A groups (OR = 1.11; 95% CI 1.07–1.15), and that blood type O individuals were consistently shown gastric cancer risk reduction (OR = 0.91; 95% CI 0.89–0.94). Our study concluded that there was a slightly increased risk of gastric cancer in blood group A individuals, and people with blood type A are more prone to be infected by H. pylori than other ABO blood type individuals, whereas, a slightly decreased risk of gastric cancer was identified in blood type O individuals.
Keywords: ABO blood group; gastric cancer; Helicobacter pylori; Asian cohort; meta-analysis
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Wang, Z.; Liu, L.; Ji, J.; Zhang, J.; Yan, M.; Zhang, J.; Liu, B.; Zhu, Z.; Yu, Y. ABO Blood Group System and Gastric Cancer: A Case-Control Study and Meta-Analysis. Int. J. Mol. Sci. 2012, 13, 13308-13321.
Wang Z, Liu L, Ji J, Zhang J, Yan M, Zhang J, Liu B, Zhu Z, Yu Y. ABO Blood Group System and Gastric Cancer: A Case-Control Study and Meta-Analysis. International Journal of Molecular Sciences. 2012; 13(10):13308-13321.
Wang, Zhiwei; Liu, Lei; Ji, Jun; Zhang, Jianian; Yan, Min; Zhang, Jun; Liu, Bingya; Zhu, Zhenggang; Yu, Yingyan. 2012. "ABO Blood Group System and Gastric Cancer: A Case-Control Study and Meta-Analysis." Int. J. Mol. Sci. 13, no. 10: 13308-13321.