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Int. J. Mol. Sci. 2012, 13(10), 13065-13078; doi:10.3390/ijms131013065

Supercritical Carbon Dioxide Extraction of Flavonoids from Pomelo (Citrus grandis (L.) Osbeck) Peel and Their Antioxidant Activity

College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China
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Received: 17 July 2012 / Revised: 11 September 2012 / Accepted: 25 September 2012 / Published: 12 October 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Supercritical carbon dioxide (SC-CO2) extraction of flavonoids from pomelo (Citrus grandis (L.) Osbeck) peel and their antioxidant activity were investigated. Box-Behnken design combined with response surface methodology was employed to maximize the extraction yield of flavonoids. Correlation analysis of the mathematical-regression model indicated that a quadratic polynomial model could be used to optimize the SC-CO2 extraction of flavonoids. The optimal conditions for obtaining the highest extraction yield of flavonoids from pomelo peel were a temperature of 80 °C, a pressure of 39 MPa and a static extraction time of 49 min in the presence of 85% ethanol as modifier. Under these conditions, the experimental yield was 2.37%, which matched positively with the value predicted by the model. Furthermore, flavonoids obtained by SC-CO2 extraction showed a higher scavenging activity on hydroxyl, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radicals than those obtained by conventional solvent extraction (CSE). Therefore, SC-CO2 extraction can be considered as a suitable technique for the obtainment of flavonoids from pomelo peel. View Full-Text
Keywords: pomelo (Citrus grandis (L.) Osbeck) peel; flavonoids; supercritical carbon dioxide (SC-CO2) extraction; response surface methodology; antioxidant activity pomelo (Citrus grandis (L.) Osbeck) peel; flavonoids; supercritical carbon dioxide (SC-CO2) extraction; response surface methodology; antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

He, J.-Z.; Shao, P.; Liu, J.-H.; Ru, Q.-M. Supercritical Carbon Dioxide Extraction of Flavonoids from Pomelo (Citrus grandis (L.) Osbeck) Peel and Their Antioxidant Activity. Int. J. Mol. Sci. 2012, 13, 13065-13078.

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