Int. J. Mol. Sci. 2012, 13(10), 12911-12924; doi:10.3390/ijms131012911
Review

Peripheral Nerve Injuries and Transplantation of Olfactory Ensheathing Cells for Axonal Regeneration and Remyelination: Fact or Fiction?

1 Department of Plastic, Hand- and Reconstructive Surgery, Hannover Medical School, 30625 Hannover, Germany 2 Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA 3 Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
* Author to whom correspondence should be addressed.
Received: 2 August 2012; in revised form: 7 September 2012 / Accepted: 7 September 2012 / Published: 10 October 2012
(This article belongs to the Special Issue Neuroprotective Strategies 2012)
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Abstract: Successful nerve regeneration after nerve trauma is not only important for the restoration of motor and sensory functions, but also to reduce the potential for abnormal sensory impulse generation that can occur following neuroma formation. Satisfying functional results after severe lesions are difficult to achieve and the development of interventional methods to achieve optimal functional recovery after peripheral nerve injury is of increasing clinical interest. Olfactory ensheathing cells (OECs) have been used to improve axonal regeneration and functional outcome in a number of studies in spinal cord injury models. The rationale is that the OECs may provide trophic support and a permissive environment for axonal regeneration. The experimental transplantation of OECs to support and enhance peripheral nerve regeneration is much more limited. This chapter reviews studies using OECs as an experimental cell therapy to improve peripheral nerve regeneration.
Keywords: peripheral nerve injury; cell transplantation; olfactory ensheathing cells; axonal regeneration; remyelination; nerve defect; nerve conduit

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MDPI and ACS Style

Radtke, C.; Kocsis, J.D. Peripheral Nerve Injuries and Transplantation of Olfactory Ensheathing Cells for Axonal Regeneration and Remyelination: Fact or Fiction? Int. J. Mol. Sci. 2012, 13, 12911-12924.

AMA Style

Radtke C, Kocsis JD. Peripheral Nerve Injuries and Transplantation of Olfactory Ensheathing Cells for Axonal Regeneration and Remyelination: Fact or Fiction? International Journal of Molecular Sciences. 2012; 13(10):12911-12924.

Chicago/Turabian Style

Radtke, Christine; Kocsis, Jeffery D. 2012. "Peripheral Nerve Injuries and Transplantation of Olfactory Ensheathing Cells for Axonal Regeneration and Remyelination: Fact or Fiction?" Int. J. Mol. Sci. 13, no. 10: 12911-12924.

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