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The Role of Glucose Transporters in Brain Disease: Diabetes and Alzheimer’s Disease
Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S. Coulter Street, Amarillo, TX 79106, USA
* Author to whom correspondence should be addressed.
Received: 1 August 2012; in revised form: 19 September 2012 / Accepted: 24 September 2012 / Published: 3 October 2012
Abstract: The occurrence of altered brain glucose metabolism has long been suggested in both diabetes and Alzheimer’s diseases. However, the preceding mechanism to altered glucose metabolism has not been well understood. Glucose enters the brain via glucose transporters primarily present at the blood-brain barrier. Any changes in glucose transporter function and expression dramatically affects brain glucose homeostasis and function. In the brains of both diabetic and Alzheimer’s disease patients, changes in glucose transporter function and expression have been observed, but a possible link between the altered glucose transporter function and disease progress is missing. Future recognition of the role of new glucose transporter isoforms in the brain may provide a better understanding of brain glucose metabolism in normal and disease states. Elucidation of clinical pathological mechanisms related to glucose transport and metabolism may provide common links to the etiology of these two diseases. Considering these facts, in this review we provide a current understanding of the vital roles of a variety of glucose transporters in the normal, diabetic and Alzheimer’s disease brain.
Keywords: glucose transporter; GLUT; SGLT; diabetes; Alzheimer’s disease; blood brain barrier; glucose metabolism
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MDPI and ACS Style
Shah, K.; DeSilva, S.; Abbruscato, T. The Role of Glucose Transporters in Brain Disease: Diabetes and Alzheimer’s Disease. Int. J. Mol. Sci. 2012, 13, 12629-12655.
Shah K, DeSilva S, Abbruscato T. The Role of Glucose Transporters in Brain Disease: Diabetes and Alzheimer’s Disease. International Journal of Molecular Sciences. 2012; 13(10):12629-12655.
Shah, Kaushik; DeSilva, Shanal; Abbruscato, Thomas. 2012. "The Role of Glucose Transporters in Brain Disease: Diabetes and Alzheimer’s Disease." Int. J. Mol. Sci. 13, no. 10: 12629-12655.