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Int. J. Mol. Sci. 2012, 13(10), 12401-12411; doi:10.3390/ijms131012401

Anti-Inflammatory and Analgesic Activities of a Novel Biflavonoid from Shells of Camellia oleifera

* ,
Pharmaceutical Engineering Department, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China
* Author to whom correspondence should be addressed.
Received: 18 July 2012 / Revised: 2 September 2012 / Accepted: 13 September 2012 / Published: 27 September 2012
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Shells are by-products of oil production from Camellia oleifera which have not been harnessed effectively. The purpose of this research is to isolate flavonoid from shells of Camellia oleifera and evaluate its anti-inflammatory and analgesic effects. The flavonoid was identified as bimolecular kaempferol structure by UV, MS, 1H NMR and 13C NMR spectra, which is a new biflavonoid and first found in Camellia oleifera. It showed dose-dependent anti-inflammatory activity by carrageenin-induced paw oedema in rats and croton oil induced ear inflammation in mice, and analgesic activity by hot plate test and acetic acid induced writhing. The mechanism of anti-inflammation of biflavonoid is related to both bradykinin and prostaglandins synthesis inhibition. The biflavonoid showed both central and peripheral analgesic effects different from aspirin, inhibition of the synthesis or action of prostaglandins may contribute to analgesic effect of biflavonoid. The biflavonoid significantly decreased malonaldehyde (MDA) and increased superoxidase dismutase (SOD) and Glutathione peroxidase (GSH-Px) activity in serum (p < 0.01), revealed strong free radical scavenging activity in vivo. It indicates the biflavonoid can control inflammation and pain by eliminating free radical so as to inhibit the mediators and decrease the prostaglandins. The biflavonoid can be used as a prospective medicine for inflammation and pain.
Keywords: biflavonoid; Camellia oleifera; anti-inflammation; analgesic activity; antioxidative activity biflavonoid; Camellia oleifera; anti-inflammation; analgesic activity; antioxidative activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ye, Y.; Guo, Y.; Luo, Y.-T. Anti-Inflammatory and Analgesic Activities of a Novel Biflavonoid from Shells of Camellia oleifera. Int. J. Mol. Sci. 2012, 13, 12401-12411.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert