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Int. J. Mol. Sci. 2011, 12(9), 5908-5945; doi:10.3390/ijms12095908
Review

Molecularly Imprinted Polymers: Present and Future Prospective

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Received: 7 June 2011 / Revised: 3 August 2011 / Accepted: 17 August 2011 / Published: 14 September 2011
(This article belongs to the Special Issue Molecular Imprinting Science and Technology)
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Abstract

Molecular Imprinting Technology (MIT) is a technique to design artificial receptors with a predetermined selectivity and specificity for a given analyte, which can be used as ideal materials in various application fields. Molecularly Imprinted Polymers (MIPs), the polymeric matrices obtained using the imprinting technology, are robust molecular recognition elements able to mimic natural recognition entities, such as antibodies and biological receptors, useful to separate and analyze complicated samples such as biological fluids and environmental samples. The scope of this review is to provide a general overview on MIPs field discussing first general aspects in MIP preparation and then dealing with various application aspects. This review aims to outline the molecularly imprinted process and present a summary of principal application fields of molecularly imprinted polymers, focusing on chemical sensing, separation science, drug delivery and catalysis. Some significant aspects about preparation and application of the molecular imprinting polymers with examples taken from the recent literature will be discussed. Theoretical and experimental parameters for MIPs design in terms of the interaction between template and polymer functionalities will be considered and synthesis methods for the improvement of MIP recognition properties will also be presented.
Keywords: molecularly imprinted polymers (MIPs); molecular imprinting technology (MIT); molecular recognition; solid phase extraction; sensors; HPLC; drug delivery; catalysis; artificial receptors molecularly imprinted polymers (MIPs); molecular imprinting technology (MIT); molecular recognition; solid phase extraction; sensors; HPLC; drug delivery; catalysis; artificial receptors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Vasapollo, G.; Sole, R.D.; Mergola, L.; Lazzoi, M.R.; Scardino, A.; Scorrano, S.; Mele, G. Molecularly Imprinted Polymers: Present and Future Prospective. Int. J. Mol. Sci. 2011, 12, 5908-5945.

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