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Int. J. Mol. Sci. 2011, 12(9), 5895-5907; doi:10.3390/ijms12095895

Looking to the Future: Biomarkers in the Management of Pancreatic Adenocarcinoma

Department of Oncology, Cross Cancer Institute, School of Cancer, Imaging and Engineering Sciences, Faculty of Medicine and Dentistry, University of Alberta, 11560 University Avenue, Edmonton, Alberta, T6G 1Z2, Canada
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Received: 5 August 2011 / Revised: 30 August 2011 / Accepted: 8 September 2011 / Published: 14 September 2011
(This article belongs to the Special Issue Biomarkers 2011)
View Full-Text   |   Download PDF [182 KB, uploaded 19 June 2014]

Abstract

The incidence and mortality of pancreas cancer converge. There has been little advancement in the treatment of pancreas cancer since the acceptance of gemcitabine as the standard therapy. Unfortunately, the efficacy of gemcitabine is dismal. While there is much discussion for the development of biomarkers to help direct therapy in this area, there is little action to move them into clinical practice. Herein, we review potential pancreatic cancer biomarkers and discuss the limitations in their implementation. View Full-Text
Keywords: pancreatic adenocarcinoma; hENT1; hCNT3; SPARC; cDK; biomarker; clinical trials; gemcitabine; oxaliplatin pancreatic adenocarcinoma; hENT1; hCNT3; SPARC; cDK; biomarker; clinical trials; gemcitabine; oxaliplatin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Spratlin, J.L.; Mulder, K.E. Looking to the Future: Biomarkers in the Management of Pancreatic Adenocarcinoma. Int. J. Mol. Sci. 2011, 12, 5895-5907.

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