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Int. J. Mol. Sci. 2011, 12(9), 5508-5521; doi:10.3390/ijms12095508

Antioxidant Protective Effect of Honey in Cigarette Smoke-Induced Testicular Damage in Rats

1
Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
2
Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
3
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
4
Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
*
Author to whom correspondence should be addressed.
Received: 13 April 2011 / Revised: 9 August 2011 / Accepted: 16 August 2011 / Published: 29 August 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Cigarette smoke (CS) can cause testicular damage and we investigated the possible protective effect of honey against CS-induced testicular damage and oxidative stress in rats. CS exposure (8 min, 3 times daily) and honey supplementation (1.2 g/kg daily) were given for 13 weeks. Rats exposed to CS significantly had smaller seminiferous tubules diameter and epithelial height, lower Leydig cell count and increased percentage of tubules with germ cell loss. CS also produced increased lipid peroxidation (TBARS) and glutathione peroxidase (GPx) activity, as well as reduced total antioxidant status (TAS) and activities of superoxide dismutase (SOD) and catalase (CAT). However, supplementation of honey significantly reduced histological changes and TBARS level, increased TAS level, as well as significantly restored activities of GPx, SOD and CAT in rat testis. These findings may suggest that honey has a protective effect against damage and oxidative stress induced by CS in rat testis. View Full-Text
Keywords: cigarette smoke; honey; testis; histology; oxidative stress cigarette smoke; honey; testis; histology; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Mohamed, M.; Sulaiman, S.A.; Jaafar, H.; Sirajudeen, K.N.S. Antioxidant Protective Effect of Honey in Cigarette Smoke-Induced Testicular Damage in Rats. Int. J. Mol. Sci. 2011, 12, 5508-5521.

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