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Int. J. Mol. Sci. 2011, 12(8), 5052-5059; doi:10.3390/ijms12085052
Article

A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population

1,†
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2,†
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4
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5
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2
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1
 and
6,*
1 Department of Immunology and Pathophysiology, Faculty of Medicine, University Carol Davila, Bucharest 041914, Romania 2 Department of Rheumatology, Faculty of Medicine, University Carol Davila, I.C. Cantacuzino Hospital, Bucharest 020475, Romania 3 Department of Rheumatology, Faculty of Medicine, University Carol Davila, St. Maria Hospital, Bucharest 011172, Romania 4 “Prof. Dr. C. T. Nicolau” National Institute of Blood Transfusion, Bucharest 011155, Romania 5 ICA Research and Development, Bucharest 013721, Romania 6 Molecular Biology Department, Grigore Antipa National Museum of Natural History, Sos. Kiseleff Nr. 1, Bucharest 011341, Romania These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 6 April 2011 / Revised: 12 July 2011 / Accepted: 1 August 2011 / Published: 8 August 2011
(This article belongs to the Section Molecular Pathology)
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Abstract

Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine implicated in the pathogenesis of psoriatic arthritis. We have performed a case-control association study of three TNF-alpha gene polymorphisms in a group of Romanian psoriatic arthritis patients versus ethnically matched controls. A second group of patients with undifferentiated spondyloarthritis was used in order to look for similarities in the genetic background of the two rheumatic disorders. The −857C/T polymorphism was associated with susceptibility to psoriatic arthritis in our population at the individual level (p = 0.03, OR 1.65, 95% CI 1.05–2.57) and in combined haplotypes with the −238G/A and −308G/A SNPs. Regarding the investigated polymorphisms and derived haplotypes, no potential association was found with the susceptibility to undifferentiated spondyloarthritis in Romanian patients.
Keywords: tumor necrosis factor alpha (TNF-alpha); psoriatic arthritis; single nucleotide polymorphism (SNP); undifferentiated spondyloarthritis tumor necrosis factor alpha (TNF-alpha); psoriatic arthritis; single nucleotide polymorphism (SNP); undifferentiated spondyloarthritis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Popa, O.M.; Bojinca, M.; Bojinca, V.; Dutescu, M.I.; Meirosu, M.; Caisan, R.E.; Ciofu, C.; Bara, C.; Popa, L.O. A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population. Int. J. Mol. Sci. 2011, 12, 5052-5059.

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