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• Popa, O
• Bojinca, M
• Bojinca, V
• Dutescu, M
• Meirosu, M
• Caisan, R
• Ciofu, C
• Bara, C
• Popa, L
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• Popa, O
• Bojinca, M
• Bojinca, V
• Dutescu, M
• Meirosu, M
• Caisan, R
• Ciofu, C
• Bara, C
• Popa, L
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• Popa, O
• Bojinca, M
• Bojinca, V
• Dutescu, M
• Meirosu, M
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• Popa, L

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Int. J. Mol. Sci. 2011, 12(8), 5052-5059; doi:10.3390/ijms12085052

Article

A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population

Olivia M. Popa ^1,† , Mihai Bojinca ^2,† , Violeta Bojinca ³ , Monica I. Dutescu ⁴ , Mihaela Meirosu ⁵ , Ruxandra E. Caisan ⁴ , Claudia Ciofu ² , Constantin Bara ¹  and Luis O. Popa ^6,*

¹ Department of Immunology and Pathophysiology, Faculty of Medicine, University Carol Davila, Bucharest 041914, Romania ² Department of Rheumatology, Faculty of Medicine, University Carol Davila, I.C. Cantacuzino Hospital, Bucharest 020475, Romania ³ Department of Rheumatology, Faculty of Medicine, University Carol Davila, St. Maria Hospital, Bucharest 011172, Romania ⁴ “Prof. Dr. C. T. Nicolau” National Institute of Blood Transfusion, Bucharest 011155, Romania ⁵ ICA Research and Development, Bucharest 013721, Romania ⁶ Molecular Biology Department, Grigore Antipa National Museum of Natural History, Sos. Kiseleff Nr. 1, Bucharest 011341, Romania ^† These authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 6 April 2011; in revised form: 12 July 2011 / Accepted: 1 August 2011 / Published: 8 August 2011

(This article belongs to the Section Molecular Pathology)

Download PDF Full-Text [158 KB, uploaded 8 August 2011 17:06 CEST]

Abstract: Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine implicated in the pathogenesis of psoriatic arthritis. We have performed a case-control association study of three TNF-alpha gene polymorphisms in a group of Romanian psoriatic arthritis patients versus ethnically matched controls. A second group of patients with undifferentiated spondyloarthritis was used in order to look for similarities in the genetic background of the two rheumatic disorders. The −857C/T polymorphism was associated with susceptibility to psoriatic arthritis in our population at the individual level (p = 0.03, OR 1.65, 95% CI 1.05–2.57) and in combined haplotypes with the −238G/A and −308G/A SNPs. Regarding the investigated polymorphisms and derived haplotypes, no potential association was found with the susceptibility to undifferentiated spondyloarthritis in Romanian patients.

Keywords: tumor necrosis factor alpha (TNF-alpha); psoriatic arthritis; single nucleotide polymorphism (SNP); undifferentiated spondyloarthritis

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