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Int. J. Mol. Sci. 2011, 12(8), 5052-5059; doi:10.3390/ijms12085052
Article

A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population

1,†
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2,†
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3
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4
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5
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4
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2
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1
 and
6,*
1 Department of Immunology and Pathophysiology, Faculty of Medicine, University Carol Davila, Bucharest 041914, Romania 2 Department of Rheumatology, Faculty of Medicine, University Carol Davila, I.C. Cantacuzino Hospital, Bucharest 020475, Romania 3 Department of Rheumatology, Faculty of Medicine, University Carol Davila, St. Maria Hospital, Bucharest 011172, Romania 4 “Prof. Dr. C. T. Nicolau” National Institute of Blood Transfusion, Bucharest 011155, Romania 5 ICA Research and Development, Bucharest 013721, Romania 6 Molecular Biology Department, Grigore Antipa National Museum of Natural History, Sos. Kiseleff Nr. 1, Bucharest 011341, Romania These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 6 April 2011 / Revised: 12 July 2011 / Accepted: 1 August 2011 / Published: 8 August 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine implicated in the pathogenesis of psoriatic arthritis. We have performed a case-control association study of three TNF-alpha gene polymorphisms in a group of Romanian psoriatic arthritis patients versus ethnically matched controls. A second group of patients with undifferentiated spondyloarthritis was used in order to look for similarities in the genetic background of the two rheumatic disorders. The −857C/T polymorphism was associated with susceptibility to psoriatic arthritis in our population at the individual level (p = 0.03, OR 1.65, 95% CI 1.05–2.57) and in combined haplotypes with the −238G/A and −308G/A SNPs. Regarding the investigated polymorphisms and derived haplotypes, no potential association was found with the susceptibility to undifferentiated spondyloarthritis in Romanian patients.
Keywords: tumor necrosis factor alpha (TNF-alpha); psoriatic arthritis; single nucleotide polymorphism (SNP); undifferentiated spondyloarthritis tumor necrosis factor alpha (TNF-alpha); psoriatic arthritis; single nucleotide polymorphism (SNP); undifferentiated spondyloarthritis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Popa, O.M.; Bojinca, M.; Bojinca, V.; Dutescu, M.I.; Meirosu, M.; Caisan, R.E.; Ciofu, C.; Bara, C.; Popa, L.O. A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population. Int. J. Mol. Sci. 2011, 12, 5052-5059.

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