Int. J. Mol. Sci. 2011, 12(8), 5039-5051; doi:10.3390/ijms12085039
Article

Potential Antibacterial Activity of Carvacrol-Loaded Poly(DL-lactide-co-glycolide) (PLGA) Nanoparticles against Microbial Biofilm

Antonio Iannitelli 1 email, Rossella Grande 1 email, Antonio Di Stefano 1,* email, Mara Di Giulio 1 email, Piera Sozio 1 email, Lucinda Janete Bessa 1 email, Sara Laserra 1 email, Cecilia Paolini 2 email, Feliciano Protasi 2 email and Luigina Cellini 1 email
1 Department of Drug Sciences, Faculty of Pharmacy, University G. d’Annunzio, Via dei Vestini 31, Chieti 66100, Italy 2 CeSI-Center for Research on Ageing & DNI-Department of Neuroscience and Imaging, University G. d’Annunzio, Chieti-Pescara, Via dei Vestini 31, Chieti 66100, Italy
* Author to whom correspondence should be addressed.
Received: 30 May 2011; in revised form: 25 July 2011 / Accepted: 26 July 2011 / Published: 8 August 2011
(This article belongs to the Section Material Sciences and Nanotechnology)
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Abstract: The ability to form biofilms contributes significantly to the pathogenesis of many microbial infections, including a variety of ocular diseases often associated with the biofilm formation on foreign materials. Carvacrol (Car.) is an important component of essential oils and recently has attracted much attention pursuant to its ability to promote microbial biofilm disruption. In the present study Car. has been encapsulated in poly(DL-lactide-co-glycolide (PLGA) nanocapsules in order to obtain a suitable drug delivery system that could represent a starting point for developing new therapeutic strategies against biofilm-associated infections, such as improving the drug effect by associating an antimicrobial agent with a biofilm viscoelasticity modifier.
Keywords: carvacrol; biofilm; PLGA nanoparticles

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MDPI and ACS Style

Iannitelli, A.; Grande, R.; Stefano, A.D.; Giulio, M.D.; Sozio, P.; Bessa, L.J.; Laserra, S.; Paolini, C.; Protasi, F.; Cellini, L. Potential Antibacterial Activity of Carvacrol-Loaded Poly(DL-lactide-co-glycolide) (PLGA) Nanoparticles against Microbial Biofilm. Int. J. Mol. Sci. 2011, 12, 5039-5051.

AMA Style

Iannitelli A, Grande R, Stefano AD, Giulio MD, Sozio P, Bessa LJ, Laserra S, Paolini C, Protasi F, Cellini L. Potential Antibacterial Activity of Carvacrol-Loaded Poly(DL-lactide-co-glycolide) (PLGA) Nanoparticles against Microbial Biofilm. International Journal of Molecular Sciences. 2011; 12(8):5039-5051.

Chicago/Turabian Style

Iannitelli, Antonio; Grande, Rossella; Stefano, Antonio Di; Giulio, Mara Di; Sozio, Piera; Bessa, Lucinda Janete; Laserra, Sara; Paolini, Cecilia; Protasi, Feliciano; Cellini, Luigina. 2011. "Potential Antibacterial Activity of Carvacrol-Loaded Poly(DL-lactide-co-glycolide) (PLGA) Nanoparticles against Microbial Biofilm." Int. J. Mol. Sci. 12, no. 8: 5039-5051.

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