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Int. J. Mol. Sci. 2011, 12(8), 5039-5051; doi:10.3390/ijms12085039

Potential Antibacterial Activity of Carvacrol-Loaded Poly(DL-lactide-co-glycolide) (PLGA) Nanoparticles against Microbial Biofilm

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1 Department of Drug Sciences, Faculty of Pharmacy, University G. d’Annunzio, Via dei Vestini 31, Chieti 66100, Italy 2 CeSI-Center for Research on Ageing & DNI-Department of Neuroscience and Imaging, University G. d’Annunzio, Chieti-Pescara, Via dei Vestini 31, Chieti 66100, Italy
* Author to whom correspondence should be addressed.
Received: 30 May 2011 / Revised: 25 July 2011 / Accepted: 26 July 2011 / Published: 8 August 2011
(This article belongs to the Section Material Sciences and Nanotechnology)
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The ability to form biofilms contributes significantly to the pathogenesis of many microbial infections, including a variety of ocular diseases often associated with the biofilm formation on foreign materials. Carvacrol (Car.) is an important component of essential oils and recently has attracted much attention pursuant to its ability to promote microbial biofilm disruption. In the present study Car. has been encapsulated in poly(DL-lactide-co-glycolide (PLGA) nanocapsules in order to obtain a suitable drug delivery system that could represent a starting point for developing new therapeutic strategies against biofilm-associated infections, such as improving the drug effect by associating an antimicrobial agent with a biofilm viscoelasticity modifier.
Keywords: carvacrol; biofilm; PLGA nanoparticles carvacrol; biofilm; PLGA nanoparticles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Iannitelli, A.; Grande, R.; Stefano, A.D.; Giulio, M.D.; Sozio, P.; Bessa, L.J.; Laserra, S.; Paolini, C.; Protasi, F.; Cellini, L. Potential Antibacterial Activity of Carvacrol-Loaded Poly(DL-lactide-co-glycolide) (PLGA) Nanoparticles against Microbial Biofilm. Int. J. Mol. Sci. 2011, 12, 5039-5051.

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