Next Article in Journal
Biodegradable Metals for Cardiovascular Stent Application: Interests and New Opportunities
Next Article in Special Issue
Enabling Anticancer Therapeutics by Nanoparticle Carriers: The Delivery of Paclitaxel
Previous Article in Journal
Molecular Cloning and Characterization of cDNA Encoding a Putative Stress-Induced Heat-Shock Protein from Camelus dromedarius
Previous Article in Special Issue
Inorganic-Organic Hybrid Nanomaterials for Therapeutic and Diagnostic Imaging Applications
Int. J. Mol. Sci. 2011, 12(7), 4237-4249; doi:10.3390/ijms12074237
Article

A Novel Preparation Method for Camptothecin (CPT) Loaded Folic Acid Conjugated Dextran Tumor-Targeted Nanoparticles

* ,
,
* ,
,
,
,
,
 and
Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin 150040, China
* Authors to whom correspondence should be addressed.
Received: 31 March 2011 / Revised: 2 June 2011 / Accepted: 21 June 2011 / Published: 28 June 2011
(This article belongs to the Special Issue Bioactive Nanoparticles (special issue))
View Full-Text   |   Download PDF [486 KB, uploaded 19 June 2014]   |   Browse Figures
SciFeed

Abstract

In this study, folic-dextran-camptothecin (Fa-DEX-CPT) tumor-targeted nanoparticles were produced with a supercritical antisolvent (SAS) technique by using dimethyl sulfoxide (DMSO) as a solvent and carbon dioxide as an antisolvent. A factorial design was used to reveal the effect of various process parameters on the mean particle size (MPS) and morphology of the particles formed. Under the optimum operation conditions, Fa-DEX-CPT nanoparticles with a MPS of 182.21 nm were obtained. Drug encapsulation efficiency and loading efficiency were 62.13% and 36.12%, respectively. It was found that the concentrations of the camptothecin (CPT) and dextran solution had a major influence upon morphology and shape of the final product. In addition, the samples were characterized by Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) with the purpose of developing a suitable targeted drug delivery system for cancer chemotherapy.
Keywords: camptothecin; dextran; supercritical antisolvent; tumor-targeted; nanoparticle camptothecin; dextran; supercritical antisolvent; tumor-targeted; nanoparticle
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Zu, Y.; Wang, D.; Zhao, X.; Jiang, R.; Zhang, Q.; Zhao, D.; Li, Y.; Zu, B.; Sun, Z. A Novel Preparation Method for Camptothecin (CPT) Loaded Folic Acid Conjugated Dextran Tumor-Targeted Nanoparticles. Int. J. Mol. Sci. 2011, 12, 4237-4249.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert