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Int. J. Mol. Sci. 2011, 12(7), 4237-4249; doi:10.3390/ijms12074237

A Novel Preparation Method for Camptothecin (CPT) Loaded Folic Acid Conjugated Dextran Tumor-Targeted Nanoparticles

Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin 150040, China
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Received: 31 March 2011 / Revised: 2 June 2011 / Accepted: 21 June 2011 / Published: 28 June 2011
(This article belongs to the Special Issue Bioactive Nanoparticles (special issue))
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Abstract

In this study, folic-dextran-camptothecin (Fa-DEX-CPT) tumor-targeted nanoparticles were produced with a supercritical antisolvent (SAS) technique by using dimethyl sulfoxide (DMSO) as a solvent and carbon dioxide as an antisolvent. A factorial design was used to reveal the effect of various process parameters on the mean particle size (MPS) and morphology of the particles formed. Under the optimum operation conditions, Fa-DEX-CPT nanoparticles with a MPS of 182.21 nm were obtained. Drug encapsulation efficiency and loading efficiency were 62.13% and 36.12%, respectively. It was found that the concentrations of the camptothecin (CPT) and dextran solution had a major influence upon morphology and shape of the final product. In addition, the samples were characterized by Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) with the purpose of developing a suitable targeted drug delivery system for cancer chemotherapy. View Full-Text
Keywords: camptothecin; dextran; supercritical antisolvent; tumor-targeted; nanoparticle camptothecin; dextran; supercritical antisolvent; tumor-targeted; nanoparticle
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zu, Y.; Wang, D.; Zhao, X.; Jiang, R.; Zhang, Q.; Zhao, D.; Li, Y.; Zu, B.; Sun, Z. A Novel Preparation Method for Camptothecin (CPT) Loaded Folic Acid Conjugated Dextran Tumor-Targeted Nanoparticles. Int. J. Mol. Sci. 2011, 12, 4237-4249.

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