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Application of Magnetic Nanoparticles to Gene Delivery
Research Team for Vascular Medicine, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
Laboratory for Medical Engineering, Division of Materials and Chemical Engineering, Yokohama National University, 79-1 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan
* Author to whom correspondence should be addressed.
Received: 6 May 2011; in revised form: 18 May 2011 / Accepted: 25 May 2011 / Published: 7 June 2011
Abstract: Nanoparticle technology is being incorporated into many areas of molecular science and biomedicine. Because nanoparticles are small enough to enter almost all areas of the body, including the circulatory system and cells, they have been and continue to be exploited for basic biomedical research as well as clinical diagnostic and therapeutic applications. For example, nanoparticles hold great promise for enabling gene therapy to reach its full potential by facilitating targeted delivery of DNA into tissues and cells. Substantial progress has been made in binding DNA to nanoparticles and controlling the behavior of these complexes. In this article, we review research on binding DNAs to nanoparticles as well as our latest study on non-viral gene delivery using polyethylenimine-coated magnetic nanoparticles.
Keywords: magnetic nanoparticles; Magnetofection; gene delivery; polyethylenimine
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Kami, D.; Takeda, S.; Itakura, Y.; Gojo, S.; Watanabe, M.; Toyoda, M. Application of Magnetic Nanoparticles to Gene Delivery. Int. J. Mol. Sci. 2011, 12, 3705-3722.
Kami D, Takeda S, Itakura Y, Gojo S, Watanabe M, Toyoda M. Application of Magnetic Nanoparticles to Gene Delivery. International Journal of Molecular Sciences. 2011; 12(6):3705-3722.
Kami, Daisuke; Takeda, Shogo; Itakura, Yoko; Gojo, Satoshi; Watanabe, Masatoshi; Toyoda, Masashi. 2011. "Application of Magnetic Nanoparticles to Gene Delivery." Int. J. Mol. Sci. 12, no. 6: 3705-3722.