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Int. J. Mol. Sci. 2011, 12(6), 3705-3722; doi:10.3390/ijms12063705

Application of Magnetic Nanoparticles to Gene Delivery

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Received: 6 May 2011 / Revised: 18 May 2011 / Accepted: 25 May 2011 / Published: 7 June 2011
(This article belongs to the Special Issue Bioactive Nanoparticles (special issue))
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Abstract: Nanoparticle technology is being incorporated into many areas of molecular science and biomedicine. Because nanoparticles are small enough to enter almost all areas of the body, including the circulatory system and cells, they have been and continue to be exploited for basic biomedical research as well as clinical diagnostic and therapeutic applications. For example, nanoparticles hold great promise for enabling gene therapy to reach its full potential by facilitating targeted delivery of DNA into tissues and cells. Substantial progress has been made in binding DNA to nanoparticles and controlling the behavior of these complexes. In this article, we review research on binding DNAs to nanoparticles as well as our latest study on non-viral gene delivery using polyethylenimine-coated magnetic nanoparticles.
Keywords: magnetic nanoparticles; Magnetofection; gene delivery; polyethylenimine magnetic nanoparticles; Magnetofection; gene delivery; polyethylenimine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kami, D.; Takeda, S.; Itakura, Y.; Gojo, S.; Watanabe, M.; Toyoda, M. Application of Magnetic Nanoparticles to Gene Delivery. Int. J. Mol. Sci. 2011, 12, 3705-3722.

AMA Style

Kami D, Takeda S, Itakura Y, Gojo S, Watanabe M, Toyoda M. Application of Magnetic Nanoparticles to Gene Delivery. International Journal of Molecular Sciences. 2011; 12(6):3705-3722.

Chicago/Turabian Style

Kami, Daisuke; Takeda, Shogo; Itakura, Yoko; Gojo, Satoshi; Watanabe, Masatoshi; Toyoda, Masashi. 2011. "Application of Magnetic Nanoparticles to Gene Delivery." Int. J. Mol. Sci. 12, no. 6: 3705-3722.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert