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Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula
AbstractIn the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100. Chemical analyses demonstrated that all polysaccharides contain heterofucans composed mainly of fucose, xylose, glucose, galactose, uronic acid, and sulfate. The fucans F0.5v and F0.7v at 1.0 mg/mL showed high ferric chelating activity (~45%), whereas fucans F1.3v (0.5 mg/mL) showed considerable reducing power, about 53.2% of the activity of vitamin C. The fucan F1.5v presented the most prominent anticoagulant activity. The best antiproliferative activity was found with fucans F1.3v and F0.7v. However, F1.3v activity was much higher than F0.7v inhibiting almost 100% of HeLa cell proliferation. These fucans have been selected for further studies on structural characterization as well as in vivo experiments, which are already in progress.
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Magalhaes, K.D.; Costa, L.S.; Fidelis, G.P.; Oliveira, R.M.; Nobre, L.T.D.B.; Dantas-Santos, N.; Camara, R.B.G.; Albuquerque, I.R.L.; Cordeiro, S.L.; Sabry, D.A.; Costa, M.S.S.P.; Alves, L.G.; Rocha, H.A.O. Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula. Int. J. Mol. Sci. 2011, 12, 3352-3365.View more citation formats
Magalhaes KD, Costa LS, Fidelis GP, Oliveira RM, Nobre LTDB, Dantas-Santos N, Camara RBG, Albuquerque IRL, Cordeiro SL, Sabry DA, Costa MSSP, Alves LG, Rocha HAO. Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula. International Journal of Molecular Sciences. 2011; 12(5):3352-3365.Chicago/Turabian Style
Magalhaes, Kaline Dantas; Costa, Leandro Silva; Fidelis, Gabriel Pereira; Oliveira, Ruth Medeiros; Nobre, Leonardo Thiago Duarte Barreto; Dantas-Santos, Nednaldo; Camara, Rafael Barros Gomes; Albuquerque, Ivan Rui Lopes; Cordeiro, Sara Lima; Sabry, Diego Araujo; Costa, Mariana Santana Santos Pereira; Alves, Luciana Guimaraes; Rocha, Hugo Alexandre Oliveira. 2011. "Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula." Int. J. Mol. Sci. 12, no. 5: 3352-3365.