Int. J. Mol. Sci. 2011, 12(5), 3352-3365; doi:10.3390/ijms12053352
Article

Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula

1 Laboratory of Biotechnology of Natural Polymers (BIOPOL), Department of Biochemistry, Federal University of Rio Grande do Norte (UFRN), 59020-100 Natal-RN, Brazil 2 Health Post-Graduate Program, Federal University of Rio Grande do Norte (UFRN), 59020-100 Natal-RN, Brazil 3 Federal Institute of Education, Science and Technology of Rio Grande do Norte (IFRN), 59200-000 Santa Cruz-RN, Brazil These authors contributed equally to the work.
* Author to whom correspondence should be addressed.
Received: 9 March 2011; in revised form: 11 April 2011 / Accepted: 19 May 2011 / Published: 23 May 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: In the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100. Chemical analyses demonstrated that all polysaccharides contain heterofucans composed mainly of fucose, xylose, glucose, galactose, uronic acid, and sulfate. The fucans F0.5v and F0.7v at 1.0 mg/mL showed high ferric chelating activity (~45%), whereas fucans F1.3v (0.5 mg/mL) showed considerable reducing power, about 53.2% of the activity of vitamin C. The fucan F1.5v presented the most prominent anticoagulant activity. The best antiproliferative activity was found with fucans F1.3v and F0.7v. However, F1.3v activity was much higher than F0.7v inhibiting almost 100% of HeLa cell proliferation. These fucans have been selected for further studies on structural characterization as well as in vivo experiments, which are already in progress.
Keywords: fucoidan; brown seaweed; biological activities; sulfated polysaccharides

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MDPI and ACS Style

Magalhaes, K.D.; Costa, L.S.; Fidelis, G.P.; Oliveira, R.M.; Nobre, L.T.D.B.; Dantas-Santos, N.; Camara, R.B.G.; Albuquerque, I.R.L.; Cordeiro, S.L.; Sabry, D.A.; Costa, M.S.S.P.; Alves, L.G.; Rocha, H.A.O. Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula. Int. J. Mol. Sci. 2011, 12, 3352-3365.

AMA Style

Magalhaes KD, Costa LS, Fidelis GP, Oliveira RM, Nobre LTDB, Dantas-Santos N, Camara RBG, Albuquerque IRL, Cordeiro SL, Sabry DA, Costa MSSP, Alves LG, Rocha HAO. Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula. International Journal of Molecular Sciences. 2011; 12(5):3352-3365.

Chicago/Turabian Style

Magalhaes, Kaline Dantas; Costa, Leandro Silva; Fidelis, Gabriel Pereira; Oliveira, Ruth Medeiros; Nobre, Leonardo Thiago Duarte Barreto; Dantas-Santos, Nednaldo; Camara, Rafael Barros Gomes; Albuquerque, Ivan Rui Lopes; Cordeiro, Sara Lima; Sabry, Diego Araujo; Costa, Mariana Santana Santos Pereira; Alves, Luciana Guimaraes; Rocha, Hugo Alexandre Oliveira. 2011. "Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula." Int. J. Mol. Sci. 12, no. 5: 3352-3365.

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