Open AccessThis article is
- freely available
Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula
Laboratory of Biotechnology of Natural Polymers (BIOPOL), Department of Biochemistry, Federal University of Rio Grande do Norte (UFRN), 59020-100 Natal-RN, Brazil
Health Post-Graduate Program, Federal University of Rio Grande do Norte (UFRN), 59020-100 Natal-RN, Brazil
Federal Institute of Education, Science and Technology of Rio Grande do Norte (IFRN), 59200-000 Santa Cruz-RN, Brazil
These authors contributed equally to the work.
* Author to whom correspondence should be addressed.
Received: 9 March 2011; in revised form: 11 April 2011 / Accepted: 19 May 2011 / Published: 23 May 2011
Abstract: In the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100. Chemical analyses demonstrated that all polysaccharides contain heterofucans composed mainly of fucose, xylose, glucose, galactose, uronic acid, and sulfate. The fucans F0.5v and F0.7v at 1.0 mg/mL showed high ferric chelating activity (~45%), whereas fucans F1.3v (0.5 mg/mL) showed considerable reducing power, about 53.2% of the activity of vitamin C. The fucan F1.5v presented the most prominent anticoagulant activity. The best antiproliferative activity was found with fucans F1.3v and F0.7v. However, F1.3v activity was much higher than F0.7v inhibiting almost 100% of HeLa cell proliferation. These fucans have been selected for further studies on structural characterization as well as in vivo experiments, which are already in progress.
Keywords: fucoidan; brown seaweed; biological activities; sulfated polysaccharides
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
Magalhaes, K.D.; Costa, L.S.; Fidelis, G.P.; Oliveira, R.M.; Nobre, L.T.D.B.; Dantas-Santos, N.; Camara, R.B.G.; Albuquerque, I.R.L.; Cordeiro, S.L.; Sabry, D.A.; Costa, M.S.S.P.; Alves, L.G.; Rocha, H.A.O. Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula. Int. J. Mol. Sci. 2011, 12, 3352-3365.
Magalhaes KD, Costa LS, Fidelis GP, Oliveira RM, Nobre LTDB, Dantas-Santos N, Camara RBG, Albuquerque IRL, Cordeiro SL, Sabry DA, Costa MSSP, Alves LG, Rocha HAO. Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula. International Journal of Molecular Sciences. 2011; 12(5):3352-3365.
Magalhaes, Kaline Dantas; Costa, Leandro Silva; Fidelis, Gabriel Pereira; Oliveira, Ruth Medeiros; Nobre, Leonardo Thiago Duarte Barreto; Dantas-Santos, Nednaldo; Camara, Rafael Barros Gomes; Albuquerque, Ivan Rui Lopes; Cordeiro, Sara Lima; Sabry, Diego Araujo; Costa, Mariana Santana Santos Pereira; Alves, Luciana Guimaraes; Rocha, Hugo Alexandre Oliveira. 2011. "Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula." Int. J. Mol. Sci. 12, no. 5: 3352-3365.