Int. J. Mol. Sci. 2011, 12(5), 3340-3351; doi:10.3390/ijms12053340
Article

Lycopene Enhances Antioxidant Enzyme Activities and Immunity Function in N-Methyl-N′-nitro-N-nitrosoguanidine–Induced Gastric Cancer Rats

1email and 2,* email
1 Chemotherapy Department, Zhejiang Cancer Hospital, Hangzhou City, Zhejiang, 310022, China 2 Department of Clinical Laboratory, Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou City, Zhejiang, 310009, China
* Author to whom correspondence should be addressed.
Received: 7 April 2011; in revised form: 27 April 2011 / Accepted: 17 May 2011 / Published: 23 May 2011
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: To investigate anticancer effect of lycopene, we examined the effects of lycopene on the oxidative injury and immunity activities of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced gastric cancer rats. The animals were divided into five groups. Group I served as the normal control and was given corn oil orally for 20 weeks. Group II were induced with MNNG 200 mg/kg body weight by oral gavage at days 0 and 14, and saturated NaCl (1 mL per rats) was given once every three days for four weeks until the end of the experimental period. Group III, IV and V were posttreated with lycopene (50, 100 and 150 mg/kg body weight, dissolved in corn oil) from the sixth week of MNNG (as in group II) induction up to the end of the experimental period. In the presence of MNNG, MDA and immunity levels were significantly increased, whereas enzymatic (SOD, CAT, and GPx) antioxidant activities were decreased in the treated rats compared with normal control rats. Administration of lycopene to gastric carcinoma-induced rats largely up-regulated the redox status and immunity activities to decrease the risk of cancer compared to group II. We conclude that up-regulation of antioxidants and immunity by lycopene treatment might be responsible for the anticancer effect in gastric carcinoma.
Keywords: lycopene; MNNG; gastric cancer; digestive tract; rat

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MDPI and ACS Style

Luo, C.; Wu, X.-G. Lycopene Enhances Antioxidant Enzyme Activities and Immunity Function in N-Methyl-N′-nitro-N-nitrosoguanidine–Induced Gastric Cancer Rats. Int. J. Mol. Sci. 2011, 12, 3340-3351.

AMA Style

Luo C, Wu X-G. Lycopene Enhances Antioxidant Enzyme Activities and Immunity Function in N-Methyl-N′-nitro-N-nitrosoguanidine–Induced Gastric Cancer Rats. International Journal of Molecular Sciences. 2011; 12(5):3340-3351.

Chicago/Turabian Style

Luo, Cong; Wu, Xian-Guo. 2011. "Lycopene Enhances Antioxidant Enzyme Activities and Immunity Function in N-Methyl-N′-nitro-N-nitrosoguanidine–Induced Gastric Cancer Rats." Int. J. Mol. Sci. 12, no. 5: 3340-3351.

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