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Int. J. Mol. Sci. 2011, 12(5), 3288-3302; doi:10.3390/ijms12053288
Article

In Vitro Antioxidant Activities of Sulfated Derivatives of Polysaccharides Extracted from Auricularia auricular

1
, 1,2,* , 1
, 1
, 3
 and 2
1 School of Food Science and Engineering, Harbin Institute of Technology, 73 HuangHe Road, NanGang District, Harbin 150090, China 2 School of Forestry, Northeast Forestry University, 26 HeXing Road, DongLi District, Harbin 150040, China 3 Symrise (Shanghai) Co., Ltd., Shanghai 201206, China
* Author to whom correspondence should be addressed.
Received: 28 March 2011 / Revised: 25 April 2011 / Accepted: 30 April 2011 / Published: 18 May 2011
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

In this research, two types of sulfated polysaccharide derivatives were successfully synthesized. Their antioxidant activities were investigated by employing various established in vitro systems. In addition, the degree of sulfation was evaluated using ion-chromatography and IR spectra. The results verify that, when employing scavenging superoxide radical tests, both the sulfation of acid Auricularia auricular polysaccharides (SAAAP) and the sulfation of neutral Auricularia auricular polysaccharides (SNAAP) derivatives possessed considerable antioxidant activity and had a more powerful antioxidant competence than that of the native non-sulfated polysaccharides (AAAP and NAAP). On the other hand, AAAP and NAAP exhibited stronger activity on scavenging both the hydroxyl radical and lipid peroxidation. Available data obtained with in vitro measurements indicates that the sulfated groups of AAAP and NAAP played an important role on antioxidant activity. In sum, the research demonstrates that the antioxidant activity of sulfated polysaccharide derivatives in vitro has a potential significance for seeking new natural antioxidant protective agents.
Keywords: polysaccharides; Auricularia auricular; sulfated derivatives; antioxidant activities; in vitro polysaccharides; Auricularia auricular; sulfated derivatives; antioxidant activities; in vitro
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, H.; Wang, Z.-Y.; Yang, L.; Yang, X.; Wang, X.; Zhang, Z. In Vitro Antioxidant Activities of Sulfated Derivatives of Polysaccharides Extracted from Auricularia auricular. Int. J. Mol. Sci. 2011, 12, 3288-3302.

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