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Int. J. Mol. Sci. 2011, 12(5), 3263-3287; doi:10.3390/ijms12053263

Microfluidic Mixing: A Review

1 Department of Materials Engineering, National Pingtung University of Science and Technology, Pingtung 912, Taiwan 2 Department of Vehicle Engineering, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
* Author to whom correspondence should be addressed.
Received: 25 March 2011 / Revised: 2 May 2011 / Accepted: 5 May 2011 / Published: 18 May 2011
(This article belongs to the Special Issue Microfluidics)


The aim of microfluidic mixing is to achieve a thorough and rapid mixing of multiple samples in microscale devices. In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows. Broadly speaking, microfluidic mixing schemes can be categorized as either “active”, where an external energy force is applied to perturb the sample species, or “passive”, where the contact area and contact time of the species samples are increased through specially-designed microchannel configurations. Many mixers have been proposed to facilitate this task over the past 10 years. Accordingly, this paper commences by providing a high level overview of the field of microfluidic mixing devices before describing some of the more significant proposals for active and passive mixers.
Keywords: active mixer; microfluidic mixing; passive micromixer active mixer; microfluidic mixing; passive micromixer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lee, C.-Y.; Chang, C.-L.; Wang, Y.-N.; Fu, L.-M. Microfluidic Mixing: A Review. Int. J. Mol. Sci. 2011, 12, 3263-3287.

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