Next Article in Journal
Antioxidant Activities of Fractions of Polymeric Procyanidins from Stem Bark of Acacia confusa
Next Article in Special Issue
Claudin 4 Is Differentially Expressed between Ovarian Cancer Subtypes and Plays a Role in Spheroid Formation
Previous Article in Journal
Effects of Intermediates between Vitamins K2 and K3 on Mammalian DNA Polymerase Inhibition and Anti-Inflammatory Activity
Previous Article in Special Issue
Role of Versican, Hyaluronan and CD44 in Ovarian Cancer Metastasis
Int. J. Mol. Sci. 2011, 12(2), 1133-1145; doi:10.3390/ijms12021133

Expression and Clinical Role of Protein of Regenerating Liver (PRL) Phosphatases in Ovarian Carcinoma

1,* , 1
1 Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel 2 Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway 3 The Medical Faculty, University of Oslo, N-0316 Oslo, Norway
* Authors to whom correspondence should be addressed.
Received: 18 November 2010 / Revised: 26 January 2011 / Accepted: 7 February 2011 / Published: 11 February 2011
(This article belongs to the Special Issue Cancer Molecules in Ovarian Cancer)
View Full-Text   |   Download PDF [462 KB, uploaded 19 June 2014]   |  


The present study analyzed the expression and clinical role of the protein of regenerating liver (PRL) phosphatase family in ovarian carcinoma. PRL1-3 mRNA expression was studied in 184 tumors (100 effusions, 57 primary carcinomas, 27 solid metastases) using RT-PCR. PRL-3 protein expression was analyzed in 157 tumors by Western blotting. PRL-1 mRNA levels were significantly higher in effusions compared to solid tumors (p
Keywords: ovarian carcinoma; effusion; metastasis; PRL phosphatases; survival ovarian carcinoma; effusion; metastasis; PRL phosphatases; survival
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Reich, R.; Hadar, S.; Davidson, B. Expression and Clinical Role of Protein of Regenerating Liver (PRL) Phosphatases in Ovarian Carcinoma. Int. J. Mol. Sci. 2011, 12, 1133-1145.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert