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Int. J. Mol. Sci. 2011, 12(2), 1133-1145; doi:10.3390/ijms12021133
Article

Expression and Clinical Role of Protein of Regenerating Liver (PRL) Phosphatases in Ovarian Carcinoma

1,* , 1
 and 2,3,*
1 Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel 2 Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway 3 The Medical Faculty, University of Oslo, N-0316 Oslo, Norway
* Authors to whom correspondence should be addressed.
Received: 18 November 2010 / Revised: 26 January 2011 / Accepted: 7 February 2011 / Published: 11 February 2011
(This article belongs to the Special Issue Cancer Molecules in Ovarian Cancer)
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Abstract

The present study analyzed the expression and clinical role of the protein of regenerating liver (PRL) phosphatase family in ovarian carcinoma. PRL1-3 mRNA expression was studied in 184 tumors (100 effusions, 57 primary carcinomas, 27 solid metastases) using RT-PCR. PRL-3 protein expression was analyzed in 157 tumors by Western blotting. PRL-1 mRNA levels were significantly higher in effusions compared to solid tumors (p
Keywords: ovarian carcinoma; effusion; metastasis; PRL phosphatases; survival ovarian carcinoma; effusion; metastasis; PRL phosphatases; survival
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Reich, R.; Hadar, S.; Davidson, B. Expression and Clinical Role of Protein of Regenerating Liver (PRL) Phosphatases in Ovarian Carcinoma. Int. J. Mol. Sci. 2011, 12, 1133-1145.

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