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Int. J. Mol. Sci. 2011, 12(2), 1133-1145; doi:10.3390/ijms12021133

Expression and Clinical Role of Protein of Regenerating Liver (PRL) Phosphatases in Ovarian Carcinoma

1
Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
2
Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway
3
The Medical Faculty, University of Oslo, N-0316 Oslo, Norway
*
Authors to whom correspondence should be addressed.
Received: 18 November 2010 / Revised: 26 January 2011 / Accepted: 7 February 2011 / Published: 11 February 2011
(This article belongs to the Special Issue Cancer Molecules in Ovarian Cancer)
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Abstract

The present study analyzed the expression and clinical role of the protein of regenerating liver (PRL) phosphatase family in ovarian carcinoma. PRL1-3 mRNA expression was studied in 184 tumors (100 effusions, 57 primary carcinomas, 27 solid metastases) using RT-PCR. PRL-3 protein expression was analyzed in 157 tumors by Western blotting. PRL-1 mRNA levels were significantly higher in effusions compared to solid tumors (p
Keywords: ovarian carcinoma; effusion; metastasis; PRL phosphatases; survival ovarian carcinoma; effusion; metastasis; PRL phosphatases; survival
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Reich, R.; Hadar, S.; Davidson, B. Expression and Clinical Role of Protein of Regenerating Liver (PRL) Phosphatases in Ovarian Carcinoma. Int. J. Mol. Sci. 2011, 12, 1133-1145.

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