The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis
Abstract
:1. What is UV?
2. Mutagenic Effects of UV Radiation
3. Sunburn Cells (UV-Induced Cell Death)
4. Role of UV in Skin Carcinogenesis
5. The E2F Family
6. E2F-Induced Apoptosis and Skin Cancer Formation
Acknowledgments
- Conflict of InterestThe authors declare no conflict of interest.
References
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UVA | UVB | |
---|---|---|
Wavelength (nm) | 320–400 | 280–320 |
Chromophores | Photosensitizers | DNA |
Site of damage | ROS | Pyrimidine dimers (CDP) 6–4 photoproducts |
Mechanism | Indirect | Direct |
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Hazar-Rethinam, M.; Endo-Munoz, L.; Gannon, O.; Saunders, N. The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis. Int. J. Mol. Sci. 2011, 12, 8947-8960. https://doi.org/10.3390/ijms12128947
Hazar-Rethinam M, Endo-Munoz L, Gannon O, Saunders N. The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis. International Journal of Molecular Sciences. 2011; 12(12):8947-8960. https://doi.org/10.3390/ijms12128947
Chicago/Turabian StyleHazar-Rethinam, Mehlika, Liliana Endo-Munoz, Orla Gannon, and Nicholas Saunders. 2011. "The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis" International Journal of Molecular Sciences 12, no. 12: 8947-8960. https://doi.org/10.3390/ijms12128947