Int. J. Mol. Sci. 2011, 12(12), 8924-8946; doi:10.3390/ijms12128924
Review

The Wnt and BMP Families of Signaling Morphogens at the Vertebrate Neuromuscular Junction

1,* email, 2email and 3email
Received: 18 October 2011; in revised form: 18 November 2011 / Accepted: 22 November 2011 / Published: 5 December 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The neuromuscular junction has been extensively employed in order to identify crucial determinants of synaptogenesis. At the vertebrate neuromuscular synapse, extracellular matrix and signaling proteins play stimulatory and inhibitory roles on the assembly of functional synapses. Studies in invertebrate species have revealed crucial functions of early morphogens during the assembly and maturation of the neuromuscular junction. Here, we discuss growing evidence addressing the function of Wnt and Bone morphogenetic protein (BMP) signaling pathways at the vertebrate neuromuscular synapse. We focus on the emerging role of Wnt proteins as positive and negative regulators of postsynaptic differentiation. We also address the possible involvement of BMP pathways on motor neuron behavior for the assembly and/or regeneration of the neuromuscular junction.
Keywords: Wnt; BMP; neuromuscular junction
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MDPI and ACS Style

Henríquez, J.P.; Krull, C.E.; Osses, N. The Wnt and BMP Families of Signaling Morphogens at the Vertebrate Neuromuscular Junction. Int. J. Mol. Sci. 2011, 12, 8924-8946.

AMA Style

Henríquez JP, Krull CE, Osses N. The Wnt and BMP Families of Signaling Morphogens at the Vertebrate Neuromuscular Junction. International Journal of Molecular Sciences. 2011; 12(12):8924-8946.

Chicago/Turabian Style

Henríquez, Juan P.; Krull, Catherine E.; Osses, Nelson. 2011. "The Wnt and BMP Families of Signaling Morphogens at the Vertebrate Neuromuscular Junction." Int. J. Mol. Sci. 12, no. 12: 8924-8946.

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