Special Issue "UV-Induced Cell Death"
Deadline for manuscript submissions: closed (15 September 2011)
Dr. Terrence Piva
School of Medical Sciences, RMIT University, PO Box 71 Bundoora, Victoria 3083, Australia
Phone: +61 3 9925 6503
Fax: +61 3 9925 7063
Interests: cell death; photobiology; photoimmunology; skin cancer; enzymology; cell metabolism; oxidative stress; cancer metabolism; cell signalling; cytokines; inflammation; enzyme kinetics; metal oxide nanoparticles; sunscreens
When we think of UV radiation we imagine getting a suntan, and sometimes when we are in the sun too long we end up getting sunburnt. Sunburnt skin cells are those, which undergo apoptosis as a result of UV exposure. Other cells in the skin can undergo necrosis. The mechanisms by which UVA, UVB and UVC trigger cell death in different cells differs depending on the cell line examined and the dose and type of UV that is used. This issue will look at the effects UV radiation has on cell death, looking at but not restricted to changes in the activity of intracellular signalling pathways, caspase activation, membrane damage, production of ROS or via direct nuclear damage and the effect this has on the cell as it dies. An often asked question is “does a cell undergoing apoptosis release molecules which may influence those around it”, hopefully this issue may help shed light on this question. For instance does a dying cell release enzymes of growth factors, which may stimulate adjacent cells to undergo cell division to replace lost cells? It is unclear if this occurs in the skin when cells are exposed to too much sunlight. I encourage you to submit a manuscript to this issue and help shed further “light” on the lethal effects UV radiation have on cells.
Prof. Dr. Terrence Piva
- ultraviolet light
- cell membrane
- signalling pathways
- enzyme activation
- sunburnt cell