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Comparative Study Using Different Infrared Zones of the Solventless Activation of Organic Reactions
Department of Chemistry, Faculty of Superior Studies Cuautitlan, Field 1, Autonomous National University of Mexico, Av. May 1st s/n, Z. C. 54740, Cuautitlan Izcalli, State of Mexico, Mexico
Mass Spectrometry Laboratory, Institute of Chemistry, Autonomous National University of Mexico, Outer City, University City, Z. C. 04510, Coyoacan, D. F., Mexico
Mass Spectrometry Laboratory, Center of Chemistry, Institute of Sciences, Benemérita University of Puebla, Z. C. 72570, Puebla, Mexico
* Author to whom correspondence should be addressed.
Received: 18 October 2011; in revised form: 21 November 2011 / Accepted: 22 November 2011 / Published: 29 November 2011
Abstract: In this work, the results of a study comparing the use of irradiation from different regions of the infrared spectrum for the promotion of several organic reactions, are presented and discussed. This use of eco-conditions provides a green approach to chemical synthesis. A set of ten different organic reactions were evaluated, including the Knoevenagel, Hantzsch, Biginelli and Meldrum reactions. It is important to highlight the use of a commercial device that produces infrared irradiation in the near infrared region and its distribution by convection providing heating uniformity, significantly reducing reaction times, achieving good yields and proceeding in the absence of solvent. It is also worth noting that a variety of different reactions may be performed at the same time. Finally, the products obtained were identified using TLC, together with corresponding MS-data, complementarily in comparison of NMR 1H and 13C data with literature information.
Keywords: solventless; comparative study; infrared irradiation; green approach
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Córdova, M.O.N.; Ramírez, C.I.F.; Bejarano, B.V.; Razo, G.A.A.; Flores, F.J.P.; Tellez, V.C.; Ruvalcaba, R.M. Comparative Study Using Different Infrared Zones of the Solventless Activation of Organic Reactions. Int. J. Mol. Sci. 2011, 12, 8575-8580.
Córdova MON, Ramírez CIF, Bejarano BV, Razo GAA, Flores FJP, Tellez VC, Ruvalcaba RM. Comparative Study Using Different Infrared Zones of the Solventless Activation of Organic Reactions. International Journal of Molecular Sciences. 2011; 12(12):8575-8580.
Córdova, María Olivia Noguez; Ramírez, Carlos I. Flores; Bejarano, Benjamín Velasco; Razo, Gabriel A. Arroyo; Flores, Francisco J. Pérez; Tellez, Vladimir Carranza; Ruvalcaba, René Miranda. 2011. "Comparative Study Using Different Infrared Zones of the Solventless Activation of Organic Reactions." Int. J. Mol. Sci. 12, no. 12: 8575-8580.