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Nanotechnology and Nanotoxicology in Retinopathy
Department of Ophthalmology, College of Medicine, Seoul National University, Seoul 110-744, Korea
Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Korea
Center for Nano-Bio Technology, Division of Convergence Technology, Korea Research Institute of Standards and Science (KRISS), Daejon 305-340, Korea
* Author to whom correspondence should be addressed.
Received: 3 November 2011; in revised form: 21 November 2011 / Accepted: 21 November 2011 / Published: 23 November 2011
Abstract: Nanoparticles are nanometer-scaled particles, and can be utilized in the form of nanocapsules, nanoconjugates, or nanoparticles themselves for the treatment of retinopathy, including angiogensis-related blindness, retinal degeneration, and uveitis. They are thought to improve the bioavailability in the retina and the permeability of therapeutic molecules across the barriers of the eye, such as the cornea, conjunctiva, and especially, blood-retinal barriers (BRBs). However, consisting of multiple neuronal cells, the retina can be the target of neuronal toxicity of nanoparticles, in common with the central and peripheral nervous system. Furthermore, the ability of nanoparticles to pass through the BRBs might increase the possibility of toxicity, simultaneously promoting distribution in the retinal layers. In this regard, we discussed nanotechnology and nanotoxicology in the treatment of retinopathy.
Keywords: blood-retinal barrier; diabetic retinopathy; macular degeneration; nanoparticles; retinal degeneration; retinal diseases; toxicology; uveitis
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MDPI and ACS Style
Jo, D.H.; Lee, T.G.; Kim, J.H. Nanotechnology and Nanotoxicology in Retinopathy. Int. J. Mol. Sci. 2011, 12, 8288-8301.
Jo DH, Lee TG, Kim JH. Nanotechnology and Nanotoxicology in Retinopathy. International Journal of Molecular Sciences. 2011; 12(11):8288-8301.
Jo, Dong Hyun; Lee, Tae Geol; Kim, Jeong Hun. 2011. "Nanotechnology and Nanotoxicology in Retinopathy." Int. J. Mol. Sci. 12, no. 11: 8288-8301.