Next Article in Journal
Characterization of a Wheat Heme Oxygenase-1 Gene and Its Responses to Different Abiotic Stresses
Next Article in Special Issue
Cell-Biomaterial Mechanical Interaction in the Framework of Tissue Engineering: Insights, Computational Modeling and Perspectives
Previous Article in Journal
Lidocaine Induces Endoplasmic Reticulum Stress-Associated Apoptosis in Vitro and in Vivo
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2011, 12(11), 7662-7691; doi:10.3390/ijms12117662

Bioengineering Embryonic Stem Cell Microenvironments for the Study of Breast Cancer

College of Nanoscale Science & Engineering, University at Albany (SUNY), Albany, NY 12202, USA
*
Author to whom correspondence should be addressed.
Received: 21 September 2011 / Revised: 27 October 2011 / Accepted: 31 October 2011 / Published: 8 November 2011
(This article belongs to the Special Issue Programmable Materials for Mechanobiology)
View Full-Text   |   Download PDF [617 KB, uploaded 19 June 2014]   |  

Abstract

Breast cancer is the most prevalent disease amongst women worldwide and metastasis is the main cause of death due to breast cancer. Metastatic breast cancer cells and embryonic stem (ES) cells display similar characteristics. However, unlike metastatic breast cancer cells, ES cells are nonmalignant. Furthermore, embryonic microenvironments have the potential to convert metastatic breast cancer cells into a less invasive phenotype. The creation of in vitro embryonic microenvironments will enable better understanding of ES cell-breast cancer cell interactions, help elucidate tumorigenesis, and lead to the restriction of breast cancer metastasis. In this article, we will present the characteristics of breast cancer cells and ES cells as well as their microenvironments, importance of embryonic microenvironments in inhibiting tumorigenesis, convergence of tumorigenic and embryonic signaling pathways, and state of the art in bioengineering embryonic microenvironments for breast cancer research. Additionally, the potential application of bioengineered embryonic microenvironments for the prevention and treatment of invasive breast cancer will be discussed.
Keywords: stem cell; microenvironment; hydrogel; three-dimensional culture; breast cancer; metastasis; co-culture stem cell; microenvironment; hydrogel; three-dimensional culture; breast cancer; metastasis; co-culture
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Raof, N.A.; Mooney, B.M.; Xie, Y. Bioengineering Embryonic Stem Cell Microenvironments for the Study of Breast Cancer. Int. J. Mol. Sci. 2011, 12, 7662-7691.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top