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Cell-Biomaterial Mechanical Interaction in the Framework of Tissue Engineering: Insights, Computational Modeling and Perspectives
School of Engineering, University of Seville, Camino de los descubrimientos s/n, 41092 Seville, Spain
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Received: 17 September 2011; in revised form: 19 October 2011 / Accepted: 2 November 2011 / Published: 21 November 2011
Abstract: Tissue engineering is an emerging field of research which combines the use of cell-seeded biomaterials both in vitro and/or in vivo with the aim of promoting new tissue formation or regeneration. In this context, how cells colonize and interact with the biomaterial is critical in order to get a functional tissue engineering product. Cell-biomaterial interaction is referred to here as the phenomenon involved in adherent cells attachment to the biomaterial surface, and their related cell functions such as growth, differentiation, migration or apoptosis. This process is inherently complex in nature involving many physico-chemical events which take place at different scales ranging from molecular to cell body (organelle) levels. Moreover, it has been demonstrated that the mechanical environment at the cell-biomaterial location may play an important role in the subsequent cell function, which remains to be elucidated. In this paper, the state-of-the-art research in the physics and mechanics of cell-biomaterial interaction is reviewed with an emphasis on focal adhesions. The paper is focused on the different models developed at different scales available to simulate certain features of cell-biomaterial interaction. A proper understanding of cell-biomaterial interaction, as well as the development of predictive models in this sense, may add some light in tissue engineering and regenerative medicine fields.
Keywords: cell mechanics; adherent cells; cell-biomaterial interaction; tissue engineering; computational modeling
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MDPI and ACS Style
Sanz-Herrera, J.A.; Reina-Romo, E. Cell-Biomaterial Mechanical Interaction in the Framework of Tissue Engineering: Insights, Computational Modeling and Perspectives. Int. J. Mol. Sci. 2011, 12, 8217-8244.
Sanz-Herrera JA, Reina-Romo E. Cell-Biomaterial Mechanical Interaction in the Framework of Tissue Engineering: Insights, Computational Modeling and Perspectives. International Journal of Molecular Sciences. 2011; 12(11):8217-8244.
Sanz-Herrera, Jose A.; Reina-Romo, Esther. 2011. "Cell-Biomaterial Mechanical Interaction in the Framework of Tissue Engineering: Insights, Computational Modeling and Perspectives." Int. J. Mol. Sci. 12, no. 11: 8217-8244.