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Study of OH● Radicals in Human Serum Blood of Healthy Individuals and Those with Pathological Schizophrenia
Tomsk Polytechnic University, Lenin av., 30, 634050, Tomsk, Russia
Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163AC A–1060 Vienna, Austria
* Author to whom correspondence should be addressed.
Received: 19 November 2010; in revised form: 29 December 2010 / Accepted: 4 January 2011 / Published: 14 January 2011
Abstract: The human body is constantly under attack from free radicals that occur as part of normal cell metabolism, and by exposure to environmental factors such as UV light, cigarette smoke, environmental pollutants and gamma radiation. The resulting “Reactive Oxygen Species” (ROS) circulate freely in the body with access to all organs and tissues, which can have serious repercussions throughout the body. The body possesses a number of mechanisms both to control the production of ROS and to cope with free radicals in order to limit or repair damage to tissues. Overproduction of ROS or insufficient defense mechanisms leads to a dangerous disbalance in the organism. Thereby several pathomechanisms implicated in over 100 human diseases, e.g., cardiovascular disease, cancer, diabetes mellitus, physiological disease, aging, etc., can be induced. Thus, a detailed investigation on the quantity of oxygen radicals, such as hydroxyl radicals (OH●) in human serum blood, and its possible correlation with antioxidant therapy effects, is highly topical. The subject of this study was the influence of schizophrenia on the amount of OH● in human serum blood. The radicals were detected by fluorimetry, using terephthalic acid as a chemical trap. For all experiments the serum blood of healthy people was used as a control group.
Keywords: human serum blood; fluorimetry; hydroxyl radicals; terephthalic acid; schizophrenia
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Korotkova, E.I.; Misini, B.; Dorozhko, E.V.; Bukkel, M.V.; Plotnikov, E.V.; Linert, W. Study of OH● Radicals in Human Serum Blood of Healthy Individuals and Those with Pathological Schizophrenia. Int. J. Mol. Sci. 2011, 12, 401-409.
Korotkova EI, Misini B, Dorozhko EV, Bukkel MV, Plotnikov EV, Linert W. Study of OH● Radicals in Human Serum Blood of Healthy Individuals and Those with Pathological Schizophrenia. International Journal of Molecular Sciences. 2011; 12(1):401-409.
Korotkova, Elena I.; Misini, Bashkim; Dorozhko, Elena V.; Bukkel, Mariya V.; Plotnikov, Evgeniy V.; Linert, Wolfgang. 2011. "Study of OH● Radicals in Human Serum Blood of Healthy Individuals and Those with Pathological Schizophrenia." Int. J. Mol. Sci. 12, no. 1: 401-409.