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Apoptotic Effects of Chrysin in Human Cancer Cell Lines
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM, Penang, Malaysia
* Author to whom correspondence should be addressed.
Received: 23 March 2010; in revised form: 3 May 2010 / Accepted: 6 May 2010 / Published: 19 May 2010
Abstract: Chrysin is a natural flavonoid currently under investigation due to its important biological anti-cancer properties. In most of the cancer cells tested, chrysin has shown to inhibit proliferation and induce apoptosis, and is more potent than other tested flavonoids in leukemia cells, where chrysin is likely to act via activation of caspases and inactivation of Akt signaling in the cells. Moreover, structure-activity relationships have revealed that the chemical structure of chrysin meets the key structural requirements of flavonoids for potent cytotoxicity in leukemia cells. It is possible that combination therapy or modified chrysin could be more potent than single-agent use or administration of unmodified chrysin. This study may help to develop ways of improving the effectiveness of chrysin in the treatment of leukemia and other human cancers in vitro.
Keywords: chrysin; apoptotic effect; human cancers; in vitro
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MDPI and ACS Style
Khoo, B.Y.; Chua, S.L.; Balaram, P. Apoptotic Effects of Chrysin in Human Cancer Cell Lines. Int. J. Mol. Sci. 2010, 11, 2188-2199.
Khoo BY, Chua SL, Balaram P. Apoptotic Effects of Chrysin in Human Cancer Cell Lines. International Journal of Molecular Sciences. 2010; 11(5):2188-2199.
Khoo, Boon Yin; Chua, Siang Ling; Balaram, Prabha. 2010. "Apoptotic Effects of Chrysin in Human Cancer Cell Lines." Int. J. Mol. Sci. 11, no. 5: 2188-2199.