Int. J. Mol. Sci. 2010, 11(5), 2067-2078; doi:10.3390/ijms11052067
Article

Antinociceptive and Anti-Inflammatory Activities of the Ethanol Extract of Annona muricata L. Leaves in Animal Models

Received: 2 April 2010; in revised form: 23 April 2010 / Accepted: 27 April 2010 / Published: 6 May 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Antinociceptive and anti-inflammatory activities of the ethanol extract from Annonamuricata L. leaves were investigated in animal models. The extract delivered per oral route (p.o.) reduced the number of abdominal contortions by 14.42% (at a dose of 200 mg/kg) and 41.41% (400 mg/kg). Doses of 200 and 400 mg/kg (p.o) inhibited both phases of the time paw licking: firstphase (23.67% and 45.02%) and the secondphase (30.09% and 50.02%), respectively. The extract (p.o.) increased the reaction time on a hot plate at doses of 200 (30.77% and 37.04%) and 400 mg/kg (82.61% and 96.30%) after 60 and 90 minutes of treatment, respectively. The paw edema was reduced by the ethanol extract (p.o.) at doses of 200 (23.16% and 29.33%) and 400 mg/kg (29.50% and 37.33%) after 3 to 4 h of application of carrageenan, respectively. Doses of 200 and 400 mg/kg (p.o.), administered 4 h before the carrageenan injection, reduced the exudate volume (29.25 and 45.74%) and leukocyte migration (18.19 and 27.95%) significantly. These results suggest that A. muricata can be an active source of substances with antinociceptive and anti-inflammatory activities.
Keywords: Annona muricata; Annonaceae; antinociceptive activity; anti-inflammatory activity
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MDPI and ACS Style

De Sousa, O.V.; Vieira, G.-V.; De Pinho, J.J.R.G.; Yamamoto, C.H.; Alves, M.S. Antinociceptive and Anti-Inflammatory Activities of the Ethanol Extract of Annona muricata L. Leaves in Animal Models. Int. J. Mol. Sci. 2010, 11, 2067-2078.

AMA Style

De Sousa OV, Vieira G-V, De Pinho JJRG, Yamamoto CH, Alves MS. Antinociceptive and Anti-Inflammatory Activities of the Ethanol Extract of Annona muricata L. Leaves in Animal Models. International Journal of Molecular Sciences. 2010; 11(5):2067-2078.

Chicago/Turabian Style

De Sousa, Orlando Vieira; Vieira, Glauciemar Del-Vechio; De Pinho, José de Jesus R. G.; Yamamoto, Célia Hitomi; Alves, Maria Silvana. 2010. "Antinociceptive and Anti-Inflammatory Activities of the Ethanol Extract of Annona muricata L. Leaves in Animal Models." Int. J. Mol. Sci. 11, no. 5: 2067-2078.

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