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Miniaturization in Biocatalysis
IBB–Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001, Lisboa, Portugal
Received: 7 January 2010; in revised form: 8 February 2010 / Accepted: 9 February 2010 / Published: 2 March 2010
Abstract: The use of biocatalysts for the production of both consumer goods and building blocks for chemical synthesis is consistently gaining relevance. A significant contribution for recent advances towards further implementation of enzymes and whole cells is related to the developments in miniature reactor technology and insights into flow behavior. Due to the high level of parallelization and reduced requirements of chemicals, intensive screening of biocatalysts and process variables has become more feasible and reproducibility of the bioconversion processes has been substantially improved. The present work aims to provide an overview of the applications of miniaturized reactors in bioconversion processes, considering multi-well plates and microfluidic devices, update information on the engineering characterization of the hardware used, and present perspective developments in this area of research.
Keywords: multi-well plates; microreactors; enzyme immobilization; flow reactors; fluidic properties
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MDPI and ACS Style
Fernandes, P. Miniaturization in Biocatalysis. Int. J. Mol. Sci. 2010, 11, 858-879.
Fernandes P. Miniaturization in Biocatalysis. International Journal of Molecular Sciences. 2010; 11(3):858-879.
Fernandes, Pedro. 2010. "Miniaturization in Biocatalysis." Int. J. Mol. Sci. 11, no. 3: 858-879.