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Int. J. Mol. Sci. 2010, 11(12), 5077-5094; doi:10.3390/ijms11125077

Colorimetric Immunoassay for Detection of Tumor Markers

1,* , 2
1 Department of Oncology, Jiangsu Province Hospital, Nanjing 210029, China 2 Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China 3 Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, China
* Authors to whom correspondence should be addressed.
Received: 7 November 2010 / Revised: 24 November 2010 / Accepted: 25 November 2010 / Published: 7 December 2010
(This article belongs to the Special Issue Biomarkers)
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Tumor markers are substances, usually proteins, produced by the body in response to cancer growth, or by the cancer tissue itself. They can be detected in blood, urine, or tissue samples, and the discovery and detection of tumor markers may provide earlier diagnosis of cancer and improved therapeutic intervention. Colorimetric immunoassays for tumor marker detection have attracted considerable attention, due to their simplicity and high efficiency. The traditionally used colorimetric immunoassays for the detection of tumor markers are based on enzyme-linked immunosorbent assays, and the great achievement of nanotechnology has further opened opportunities for the development of such kind of immunoassays. This paper will summarize recent advances in the field of colorimetric immunoassays for detecting tumor markers, which is aimed to provide an overview in this field, as well as experimental guidance for the learner.
Keywords: tumor markers; colorimetric immunoassay; nanomaterials tumor markers; colorimetric immunoassay; nanomaterials
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yin, Y.; Cao, Y.; Xu, Y.; Li, G. Colorimetric Immunoassay for Detection of Tumor Markers. Int. J. Mol. Sci. 2010, 11, 5077-5094.

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