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Protein Microarrays and Biomarkers of Infectious Disease
Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA
* Author to whom correspondence should be addressed.
Received: 19 November 2010; in revised form: 11 December 2010 / Accepted: 15 December 2010 / Published: 16 December 2010
(This article belongs to the Special Issue Biomarkers
Abstract: Protein microarrays are powerful tools that are widely used in systems biology research. For infectious diseases, proteome microarrays assembled from proteins of pathogens will play an increasingly important role in discovery of diagnostic markers, vaccines, and therapeutics. Distinct formats of protein microarrays have been developed for different applications, including abundance-based and function-based methods. Depending on the application, design issues should be considered, such as the need for multiplexing and label or label free detection methods. New developments, challenges, and future demands in infectious disease research will impact the application of protein microarrays for discovery and validation of biomarkers.
Keywords: protein microarray; infectious diseases; biomarkers
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Cite This Article
MDPI and ACS Style
Natesan, M.; Ulrich, R.G. Protein Microarrays and Biomarkers of Infectious Disease. Int. J. Mol. Sci. 2010, 11, 5165-5183.
Natesan M, Ulrich RG. Protein Microarrays and Biomarkers of Infectious Disease. International Journal of Molecular Sciences. 2010; 11(12):5165-5183.
Natesan, Mohan; Ulrich, Robert G. 2010. "Protein Microarrays and Biomarkers of Infectious Disease." Int. J. Mol. Sci. 11, no. 12: 5165-5183.