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Int. J. Mol. Sci. 2010, 11(12), 5165-5183; doi:10.3390/ijms11125165

Protein Microarrays and Biomarkers of Infectious Disease

*  and
Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA
* Author to whom correspondence should be addressed.
Received: 19 November 2010 / Revised: 11 December 2010 / Accepted: 15 December 2010 / Published: 16 December 2010
(This article belongs to the Special Issue Biomarkers)
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Protein microarrays are powerful tools that are widely used in systems biology research. For infectious diseases, proteome microarrays assembled from proteins of pathogens will play an increasingly important role in discovery of diagnostic markers, vaccines, and therapeutics. Distinct formats of protein microarrays have been developed for different applications, including abundance-based and function-based methods. Depending on the application, design issues should be considered, such as the need for multiplexing and label or label free detection methods. New developments, challenges, and future demands in infectious disease research will impact the application of protein microarrays for discovery and validation of biomarkers.
Keywords: protein microarray; infectious diseases; biomarkers protein microarray; infectious diseases; biomarkers
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Natesan, M.; Ulrich, R.G. Protein Microarrays and Biomarkers of Infectious Disease. Int. J. Mol. Sci. 2010, 11, 5165-5183.

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