Int. J. Mol. Sci. 2010, 11(12), 4796-4813; doi:10.3390/ijms11124796
Review

Functional Toxicogenomics: Mechanism-Centered Toxicology

email and * email
Received: 29 September 2010; in revised form: 22 November 2010 / Accepted: 22 November 2010 / Published: 24 November 2010
(This article belongs to the Special Issue Advances in Molecular Toxicology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Traditional toxicity testing using animal models is slow, low capacity, expensive and assesses a limited number of endpoints. Such approaches are inadequate to deal with the increasingly large number of compounds found in the environment for which there are no toxicity data. Mechanism-centered high-throughput testing represents an alternative approach to meet this pressing need but is limited by our current understanding of toxicity pathways. Functional toxicogenomics, the global study of the biological function of genes on the modulation of the toxic effect of a compound, can play an important role in identifying the essential cellular components and pathways involved in toxicity response. The combination of the identification of fundamental toxicity pathways and mechanism-centered targeted assays represents an integrated approach to advance molecular toxicology to meet the challenges of toxicity testing in the 21st century.
Keywords: toxicity testing; functional toxicogenomics; toxicity pathways; barcoding; yeast
PDF Full-text Download PDF Full-Text [147 KB, uploaded 19 June 2014 03:19 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

North, M.; Vulpe, C.D. Functional Toxicogenomics: Mechanism-Centered Toxicology. Int. J. Mol. Sci. 2010, 11, 4796-4813.

AMA Style

North M, Vulpe CD. Functional Toxicogenomics: Mechanism-Centered Toxicology. International Journal of Molecular Sciences. 2010; 11(12):4796-4813.

Chicago/Turabian Style

North, Matthew; Vulpe, Chris D. 2010. "Functional Toxicogenomics: Mechanism-Centered Toxicology." Int. J. Mol. Sci. 11, no. 12: 4796-4813.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert