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Int. J. Mol. Sci. 2010, 11(12), 4782-4795; doi:10.3390/ijms11124782
Article

Anti-Photoaging Effects of Soy Isoflavone Extract (Aglycone and Acetylglucoside Form) from Soybean Cake

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Received: 22 October 2010; in revised form: 16 November 2010 / Accepted: 17 November 2010 / Published: 24 November 2010
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: Soy isoflavones, found in soybean and soybean products, have been reported to possess many physiological activities such as antioxidant activity, inhibition of cancer cell proliferation, reduction of cardiovascular risk, prevention of osteoporosis and alleviation of postmenopausal syndrome. In our previous study, soy isoflavone extract ISO-1 (containing 12 soy isoflavones) from soybean cake was demonstrated to prevent skin damage caused by UVB exposure. In this study, soy isoflavone extract from soybean cake was further purified and evaluated for the protective effects on UVB-induced damage. The results revealed that Fraction 3, which contains the aglycone group (daidzein, genistein and glycitein) and acetylglucoside group (acetyldaidzin, acetylgenistin and acetylglycitin) of soy isoflavones, could inhibit UVB-induced death of human keratinocytes and reduce the level of desquamation, transepidermal water loss (TEWL), erythema and epidermal thickness in mouse skin. Furthermore, topical application of Fraction 3 increased the activity of catalase and suppressed cyclooxygenase-2 (COX-2) and proliferating cell nuclear antigen (PCNA) expression in mice exposed to UVB. In addition, in comparison with ISO-1 and genistein, the Fraction 3 possessed much greater protective effects on both UVB-induced oxidative stress and keratinocyte death than other fractions. Therefore, the soy isoflavone extract Fraction 3 from soybean cake is a desirable anti-photoaging agent for skin care.
Keywords: isoflavone; aglycone; acetylglucoside; UVB; catalase; COX-2 isoflavone; aglycone; acetylglucoside; UVB; catalase; COX-2
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, C.-C.; Hsu, B.-Y.; Wu, N.-L.; Tsui, W.-H.; Lin, T.-J.; Su, C.-C.; Hung, C.-F. Anti-Photoaging Effects of Soy Isoflavone Extract (Aglycone and Acetylglucoside Form) from Soybean Cake. Int. J. Mol. Sci. 2010, 11, 4782-4795.

AMA Style

Huang C-C, Hsu B-Y, Wu N-L, Tsui W-H, Lin T-J, Su C-C, Hung C-F. Anti-Photoaging Effects of Soy Isoflavone Extract (Aglycone and Acetylglucoside Form) from Soybean Cake. International Journal of Molecular Sciences. 2010; 11(12):4782-4795.

Chicago/Turabian Style

Huang, Chieh-Chen; Hsu, Bo-Yang; Wu, Nan-Lin; Tsui, Wen-Huei; Lin, Tzu-Ju; Su, Ching-Chieh; Hung, Chi-Feng. 2010. "Anti-Photoaging Effects of Soy Isoflavone Extract (Aglycone and Acetylglucoside Form) from Soybean Cake." Int. J. Mol. Sci. 11, no. 12: 4782-4795.


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